| http://purl.uniprot.org/citations/18278055 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18278055 | http://www.w3.org/2000/01/rdf-schema#comment | "The proteasome is the central regulatory protease of eukaryotic cells. Heteroheptameric alpha-subunit and beta-subunit rings stack to form the 20S proteasome, which associates with a 19S regulatory particle (RP). Here we show that two yeast proteins, Pba3 and Pba4, form a previously unidentified 20S proteasome-assembly chaperone. Pba3-Pba4 interacts genetically and physically with specific proteasomal alpha subunits, and loss of Pba3-Pba4 causes both a reduction and a remodeling of cellular proteasomes. Notably, mutant cells accumulate proteasomes in which a second copy of the alpha4 subunit replaces alpha3. 20S proteasome-assembly defects also are associated with altered RP assembly; this unexpected result suggests that the 20S proteasome can function as an RP-assembly factor in vivo. Our data demonstrate that Pba3-Pba4 orchestrates formation of a specific type of proteasome, the first example of a trans-acting factor that controls assembly of alternative proteasomal complexes."xsd:string |
| http://purl.uniprot.org/citations/18278055 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.1389"xsd:string |
| http://purl.uniprot.org/citations/18278055 | http://purl.uniprot.org/core/author | "Funakoshi M."xsd:string |
| http://purl.uniprot.org/citations/18278055 | http://purl.uniprot.org/core/author | "Hochstrasser M."xsd:string |
| http://purl.uniprot.org/citations/18278055 | http://purl.uniprot.org/core/author | "Kusmierczyk A.R."xsd:string |
| http://purl.uniprot.org/citations/18278055 | http://purl.uniprot.org/core/author | "Kunjappu M.J."xsd:string |
| http://purl.uniprot.org/citations/18278055 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18278055 | http://purl.uniprot.org/core/name | "Nat Struct Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/18278055 | http://purl.uniprot.org/core/pages | "237-244"xsd:string |
| http://purl.uniprot.org/citations/18278055 | http://purl.uniprot.org/core/title | "A multimeric assembly factor controls the formation of alternative 20S proteasomes."xsd:string |
| http://purl.uniprot.org/citations/18278055 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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