| http://purl.uniprot.org/citations/18280249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18280249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18280249 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor NF-kappaB plays an important role in inflammation and cell survival. Here, we report the functional characterization of URP2SF (UNC-112 related protein 2 short form), which is a novel protein containing FERM and PH domains. The protein is conserved in evolution across different species. Northern blot and RT-PCR analysis revealed that the expression of URP2SF appeared to be primarily confined to immune system. URP2SF protein localized to the whole cell. Over-expression of URP2SF strongly repressed NF-kappaB activity in the absence or presence of NF-kappaB stimulus. Importantly, URP2SF over-expression also induced cell apoptosis. Furthermore, suppression of URP2SF expression by small interference RNA significantly activated the NF-kappaB reporter gene activities, as well as attenuated TNF-alpha induced apoptosis. Therefore, our data show for the first time that URP2SF may act as a transcriptional repressor in NF-kappaB signaling pathway and regulate cell apoptotic pathway."xsd:string |
| http://purl.uniprot.org/citations/18280249 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2008.02.024"xsd:string |
| http://purl.uniprot.org/citations/18280249 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2008.02.024"xsd:string |
| http://purl.uniprot.org/citations/18280249 | http://purl.uniprot.org/core/author | "Deng W."xsd:string |
| http://purl.uniprot.org/citations/18280249 | http://purl.uniprot.org/core/author | "Deng W."xsd:string |
| http://purl.uniprot.org/citations/18280249 | http://purl.uniprot.org/core/author | "Ma D."xsd:string |
| http://purl.uniprot.org/citations/18280249 | http://purl.uniprot.org/core/author | "Ma D."xsd:string |
| http://purl.uniprot.org/citations/18280249 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/18280249 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/18280249 | http://purl.uniprot.org/core/author | "Shi T."xsd:string |
| http://purl.uniprot.org/citations/18280249 | http://purl.uniprot.org/core/author | "Shi T."xsd:string |
| http://purl.uniprot.org/citations/18280249 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18280249 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18280249 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/18280249 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/18280249 | http://purl.uniprot.org/core/pages | "899-906"xsd:string |
| http://purl.uniprot.org/citations/18280249 | http://purl.uniprot.org/core/pages | "899-906"xsd:string |
| http://purl.uniprot.org/citations/18280249 | http://purl.uniprot.org/core/title | "URP2SF, a FERM and PH domain containing protein, regulates NF-kappaB and apoptosis."xsd:string |
| http://purl.uniprot.org/citations/18280249 | http://purl.uniprot.org/core/title | "URP2SF, a FERM and PH domain containing protein, regulates NF-kappaB and apoptosis."xsd:string |
| http://purl.uniprot.org/citations/18280249 | http://purl.uniprot.org/core/volume | "368"xsd:string |
| http://purl.uniprot.org/citations/18280249 | http://purl.uniprot.org/core/volume | "368"xsd:string |
| http://purl.uniprot.org/citations/18280249 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18280249 |
| http://purl.uniprot.org/citations/18280249 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18280249 |