| http://purl.uniprot.org/citations/18280640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18280640 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-6 (IL-6) is a multifunctional cytokine involved in autoimmune thyroid diseases such as Hashimoto's thyroiditis and Graves' disease. IL-6 is produced by infiltrating immune cells and by thyrocytes. In the latter cell type, secretion of IL-6 is stimulated notably by interleukin-1 (IL-1), thyroid-stimulating hormone (TSH) or forskolin (Fk), a cAMP elevating agent. We report here that Fk and IL-1 synergistically enhance IL-6 mRNA expression in FRTL-5 thyroid cells by mechanisms involving the cAMP/PKA pathway, and both stabilization of the IL-6 mRNA and activation of the IL-6 promoter. Point mutations or deletions of the main transcription factor binding sites in the IL-6 promoter indicated that the synergistic effect was mainly mediated by the AP-1 site, and that the CRE site contributed to this effect. The DNA binding activity of AP-1 transcription factors and the expression of c-Fos and Fra-2 proteins, were all enhanced when the cAMP and IL-1 signalling pathways were both stimulated. These findings contribute to elucidating the synergistic mechanisms that regulate IL-6 secretion by thyroid cells, and suggest that such mechanisms may be involved in the development of thyroid autoimmune disorders."xsd:string |
| http://purl.uniprot.org/citations/18280640 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mce.2007.12.017"xsd:string |
| http://purl.uniprot.org/citations/18280640 | http://purl.uniprot.org/core/author | "Pomerance M."xsd:string |
| http://purl.uniprot.org/citations/18280640 | http://purl.uniprot.org/core/author | "Blondeau J.P."xsd:string |
| http://purl.uniprot.org/citations/18280640 | http://purl.uniprot.org/core/author | "Szabo-Fresnais N."xsd:string |
| http://purl.uniprot.org/citations/18280640 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18280640 | http://purl.uniprot.org/core/name | "Mol Cell Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/18280640 | http://purl.uniprot.org/core/pages | "28-37"xsd:string |
| http://purl.uniprot.org/citations/18280640 | http://purl.uniprot.org/core/title | "Activation of the cAMP pathway synergistically increases IL-1-induced IL-6 gene expression in FRTL-5 thyroid cells: involvement of AP-1 transcription factors."xsd:string |
| http://purl.uniprot.org/citations/18280640 | http://purl.uniprot.org/core/volume | "284"xsd:string |
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