| http://purl.uniprot.org/citations/18281438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18281438 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29 are new members of the IL-10 interferon family. Monocytes are well-known sources of IL-19, IL-20, and IL-24. We demonstrated here that monocytes also expressed IL-29, and monocyte differentiation into macrophages (Mphi) or dendritic cells (DCs) strongly changed their production capacity of these cytokines. Maturation of DCs with bacterial stimuli induced high expression of IL-28/IL-29 and IL-20. Simulated T cell interaction and inflammatory cytokines induced IL-29 and IL-20 in maturing DCs, respectively. Compared with monocytes, DCs expressed only minimal IL-19 levels and no IL-24. The differentiation of monocytes into Mphi reduced their IL-19 and terminated their IL-20, IL-24, and IL-29 production capacity. Like monocytes, neither Mphi nor DCs expressed IL-22 or IL-26. The importance of maturing DCs as a source of IL-28/IL-29 was supported by the much higher mRNA levels of these mediators in maturing DCs compared with those in CMV-infected fibroblasts, and the presence of IL-28 in lymph nodes but not in liver of lipopolysaccharide-injected mice. IL-19, IL-20, IL-22, IL-24, and IL-26 do not seem to affect Mphi or DCs as deduced from the lack of corresponding receptor chains. The significance of IL-20 and IL-28/IL-29 coexpression in maturing DCs may lie in the broadly amplified innate immunity in neighboring tissue cells like keratinocytes. In fact, IL-20 induced the expression of antimicrobial proteins, whereas IL-28/IL-29 enhanced the expression of toll-like receptors (TLRs) and the response to TLR ligands. However, the strongest response to TLR2 and TLR3 activation showed keratinocytes in the simultaneous presence of IL-20 and IL-29."xsd:string |
| http://purl.uniprot.org/citations/18281438 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.0807525"xsd:string |
| http://purl.uniprot.org/citations/18281438 | http://purl.uniprot.org/core/author | "Proesch S."xsd:string |
| http://purl.uniprot.org/citations/18281438 | http://purl.uniprot.org/core/author | "Witte K."xsd:string |
| http://purl.uniprot.org/citations/18281438 | http://purl.uniprot.org/core/author | "Sterry W."xsd:string |
| http://purl.uniprot.org/citations/18281438 | http://purl.uniprot.org/core/author | "Asadullah K."xsd:string |
| http://purl.uniprot.org/citations/18281438 | http://purl.uniprot.org/core/author | "Sabat R."xsd:string |
| http://purl.uniprot.org/citations/18281438 | http://purl.uniprot.org/core/author | "Volk H.D."xsd:string |
| http://purl.uniprot.org/citations/18281438 | http://purl.uniprot.org/core/author | "Witte E."xsd:string |
| http://purl.uniprot.org/citations/18281438 | http://purl.uniprot.org/core/author | "Wolk K."xsd:string |
| http://purl.uniprot.org/citations/18281438 | http://purl.uniprot.org/core/author | "Schulze-Tanzil G."xsd:string |
| http://purl.uniprot.org/citations/18281438 | http://purl.uniprot.org/core/author | "Nasilowska K."xsd:string |
| http://purl.uniprot.org/citations/18281438 | http://purl.uniprot.org/core/author | "Thilo J."xsd:string |
| http://purl.uniprot.org/citations/18281438 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18281438 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/18281438 | http://purl.uniprot.org/core/pages | "1181-1193"xsd:string |
| http://purl.uniprot.org/citations/18281438 | http://purl.uniprot.org/core/title | "Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes."xsd:string |
| http://purl.uniprot.org/citations/18281438 | http://purl.uniprot.org/core/volume | "83"xsd:string |
| http://purl.uniprot.org/citations/18281438 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18281438 |
| http://purl.uniprot.org/citations/18281438 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18281438 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C391-mappedCitation-18281438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18281438 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C4W0-mappedCitation-18281438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18281438 |
| http://purl.uniprot.org/uniprot/#_E2JF13-mappedCitation-18281438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18281438 |
| http://purl.uniprot.org/uniprot/#_G9C945-mappedCitation-18281438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18281438 |