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http://purl.uniprot.org/citations/18282752http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18282752http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

Polymorphisms in the major histocompatibility complex class I chain-related gene A may influence its binding to the Natural Killer Cell Receptor G2D (NKG2D). We looked for polymorphisms in major histocompatibility complex class I chain-related gene A exon 5 and in Human Leukocyte Antigen (HLA)-DQ/DR in adult coeliac disease patients to determine whether they affected coeliac disease phenotypes.

Methods

Adult coeliac disease patients with (n=98) and without (n=93) gastrointestinal symptoms (gastrointestinal symptoms+/gastrointestinal symptoms-) and 108 control subjects from Campania (Italy) were characterized by Polymerase Chain Reaction (PCR) sequence specific oligonucleotide followed by PCR sequence specific primer assays for HLA DQ/DR, and by PCR followed by capillary electrophoresis for major histocompatibility complex class I chain-related gene A exon 5 polymorphisms. Immunoglobulin A (IgA) anti-transglutaminase antibodies were also evaluated by immunosorbent assay.

Results

Five different major histocompatibility complex class I chain-related gene A alleles were detected in both coeliac disease patients and control subjects. The major histocompatibility complex class I chain-related gene A 5.1 allele occurred more frequently in patients than in controls (p<0.05), and the major histocompatibility complex class I chain-related gene A 5.1/5.1 homozygous genotype increased the risk of gastrointestinal symptoms-coeliac disease (OR=2.79, 95% CI 1.15-6.79). Gastrointestinal symptoms-coeliac disease patients bearing major histocompatibility complex class I chain-related gene A 5.1/5.1 alleles showed lower anti-transglutaminase levels (18U/L) than the gastrointestinal symptoms+ coeliac disease patients (35U/L). HLA-DQ2/DQ8 genotypes did not differ between gastrointestinal symptoms+ and gastrointestinal symptoms-coeliac disease, although DQ8 tended to be more frequent in gastrointestinal symptoms-coeliac disease (11.7%) than in gastrointestinal symptoms+ coeliac disease (6%).

Conclusions

Our study shows that a double dose of the major histocompatibility complex class I chain-related gene A 5.1 allele could predispose to the onset of gastrointestinal symptoms-coeliac disease. We can hypothesize that a lower level of immunological involvement in gastrointestinal symptoms-coeliac disease patients is associated with absence of gastrointestinal symptoms. This test could represent a second step in the genetic typing of high-risk subjects such as first-degree relatives of coeliac disease patients positive for the DQ2/DQ8 molecule."xsd:string
http://purl.uniprot.org/citations/18282752http://purl.org/dc/terms/identifier"doi:10.1016/j.dld.2007.11.028"xsd:string
http://purl.uniprot.org/citations/18282752http://purl.uniprot.org/core/author"Calcagno G."xsd:string
http://purl.uniprot.org/citations/18282752http://purl.uniprot.org/core/author"Tinto N."xsd:string
http://purl.uniprot.org/citations/18282752http://purl.uniprot.org/core/author"Ciacci C."xsd:string
http://purl.uniprot.org/citations/18282752http://purl.uniprot.org/core/author"Farinaro E."xsd:string
http://purl.uniprot.org/citations/18282752http://purl.uniprot.org/core/author"Sacchetti L."xsd:string
http://purl.uniprot.org/citations/18282752http://purl.uniprot.org/core/author"Gennarelli D."xsd:string
http://purl.uniprot.org/citations/18282752http://purl.uniprot.org/core/author"Spampanato A."xsd:string
http://purl.uniprot.org/citations/18282752http://purl.uniprot.org/core/author"Tortora R."xsd:string
http://purl.uniprot.org/citations/18282752http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18282752http://purl.uniprot.org/core/name"Dig Liver Dis"xsd:string
http://purl.uniprot.org/citations/18282752http://purl.uniprot.org/core/pages"248-252"xsd:string
http://purl.uniprot.org/citations/18282752http://purl.uniprot.org/core/title"Increased prevalence of celiac disease without gastrointestinal symptoms in adults MICA 5.1 homozygous subjects from the Campania area."xsd:string
http://purl.uniprot.org/citations/18282752http://purl.uniprot.org/core/volume"40"xsd:string
http://purl.uniprot.org/citations/18282752http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18282752
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