| http://purl.uniprot.org/citations/1828291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1828291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1828291 | http://www.w3.org/2000/01/rdf-schema#comment | "In rapidly growing cells of the budding yeast Saccharomyces cerevisiae, the cell cycle is regulated chiefly at Start, just before the G1-S boundary, whereas in the fission yeast Schizosaccharomyces pombe, the cycle is predominantly regulated at G2-M. Both control points are present in both yeasts, and both require the p34cdc2 protein kinase. At G2-M, p34cdc2 kinase activity in S. pombe requires a B-type cyclin in a complex with p34cdc2; this complex is the same as MPF (maturation promoting factor). The p34cdc2 activity at the G1-S transition in S. cerevisiae may be regulated by a similar cyclin complex, using one of the products of a new class of cyclin genes (CLN1, CLN2 and WHI1 (DAF1/CLN3)). At least one is required for progression through the G1-S phase, and deletion of all three leads to G1 arrest. WHI1 was isolated as a dominant allele causing budding yeast cells to divide at a reduced size and was later independently identified as DAF1, a dominant allele of which rendered the cells refractory to the G1-arrest induced by the mating pheromone alpha-factor. The dominant alleles are truncations thought to yield proteins of increased stability, and the cells are accelerated through G1. Without WHI1 function, the cells are hypersensitive to alpha-factor, enlarged and delayed in G1. Heretofore, this G1-class of cyclins has not been identified in other organisms. We have isolated a G1-type cyclin gene called puc1+ from S. pombe, using a functional assay in S. cerevisiae. Expression of puc1+ in S. pombe indicates that it has a cyclin-like role in the fission yeast distinct from the role of the B-type mitotic cyclin."xsd:string |
| http://purl.uniprot.org/citations/1828291 | http://purl.org/dc/terms/identifier | "doi:10.1038/351245a0"xsd:string |
| http://purl.uniprot.org/citations/1828291 | http://purl.org/dc/terms/identifier | "doi:10.1038/351245a0"xsd:string |
| http://purl.uniprot.org/citations/1828291 | http://purl.uniprot.org/core/author | "Forsburg S.L."xsd:string |
| http://purl.uniprot.org/citations/1828291 | http://purl.uniprot.org/core/author | "Forsburg S.L."xsd:string |
| http://purl.uniprot.org/citations/1828291 | http://purl.uniprot.org/core/author | "Nurse P."xsd:string |
| http://purl.uniprot.org/citations/1828291 | http://purl.uniprot.org/core/author | "Nurse P."xsd:string |
| http://purl.uniprot.org/citations/1828291 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1828291 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1828291 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/1828291 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/1828291 | http://purl.uniprot.org/core/pages | "245-247"xsd:string |
| http://purl.uniprot.org/citations/1828291 | http://purl.uniprot.org/core/pages | "245-247"xsd:string |
| http://purl.uniprot.org/citations/1828291 | http://purl.uniprot.org/core/title | "Identification of a G1-type cyclin puc1+ in the fission yeast Schizosaccharomyces pombe."xsd:string |
| http://purl.uniprot.org/citations/1828291 | http://purl.uniprot.org/core/title | "Identification of a G1-type cyclin puc1+ in the fission yeast Schizosaccharomyces pombe."xsd:string |
| http://purl.uniprot.org/citations/1828291 | http://purl.uniprot.org/core/volume | "351"xsd:string |
| http://purl.uniprot.org/citations/1828291 | http://purl.uniprot.org/core/volume | "351"xsd:string |
| http://purl.uniprot.org/citations/1828291 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1828291 |
| http://purl.uniprot.org/citations/1828291 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1828291 |
| http://purl.uniprot.org/citations/1828291 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1828291 |
| http://purl.uniprot.org/citations/1828291 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1828291 |
| http://purl.uniprot.org/citations/1828291 | http://purl.uniprot.org/core/erratum | http://purl.uniprot.org/citations/SIPA0187546A4EFA90F |
| http://purl.uniprot.org/uniprot/P25009 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/1828291 |