| http://purl.uniprot.org/citations/18284215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18284215 | http://www.w3.org/2000/01/rdf-schema#comment | "Vascular smooth muscle cells (SMCs), one of the major cell types of the vascular wall, play a critical role in the process of angiogenesis under both physiological and pathophysiological conditions, including the cancer microenvironment. Previous studies have shown that VEGF-A 165 augments vascular SMC migration via VEGFR2 (KDR/Flk1) pathways. In this study, we found that VEGF-A 165 (recombinant protein or breast tumor cell-secreted) is also capable of inducing migration of VEGFR2-negative human aortic smooth muscle cells (hAOSMCs), and this induction is mediated through a molecular cross-talk of neuropilin-1 (NRP-1), VEGFR1 (Flt-1), and phosphoinositide 3-kinase (PI3K)/Akt signaling kinase. We found that VEGF-A 165 induces hAOSMC migration parallel with the induction of NRP-1 and VEGFR1 expressions and their associations along with the activation of PI3K/Akt. Neutralization of VEGF action by its antibody or inhibition of VEGF-induced PI3K/Akt kinase activation by wortmannin, a PI3K/Akt specific inhibitor, results in inhibition of VEGF-induced hAOSMC migration. Moreover, RNAi-mediated elimination of the NRP-1 expression or blocking of the activity of VEGFR1 by its antibody in hAOSMCs impairs the VEGF-A 165-induced migration of these cells as well as activation of PI3K/Akt kinase. Collectively, these results establish, for the first time, a mechanistic link among VEGF-A 165, NRP-1, VEGFR1, and PI3K/Akt in the regulation of migration of human vascular smooth muscle cells that eventually could be involved in the angiogenic switch."xsd:string |
| http://purl.uniprot.org/citations/18284215 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi8000352"xsd:string |
| http://purl.uniprot.org/citations/18284215 | http://purl.uniprot.org/core/author | "Mehta S."xsd:string |
| http://purl.uniprot.org/citations/18284215 | http://purl.uniprot.org/core/author | "Banerjee S."xsd:string |
| http://purl.uniprot.org/citations/18284215 | http://purl.uniprot.org/core/author | "Kambhampati S."xsd:string |
| http://purl.uniprot.org/citations/18284215 | http://purl.uniprot.org/core/author | "Dhar K."xsd:string |
| http://purl.uniprot.org/citations/18284215 | http://purl.uniprot.org/core/author | "Banerjee S.K."xsd:string |
| http://purl.uniprot.org/citations/18284215 | http://purl.uniprot.org/core/author | "Sengupta K."xsd:string |
| http://purl.uniprot.org/citations/18284215 | http://purl.uniprot.org/core/author | "Haque I."xsd:string |
| http://purl.uniprot.org/citations/18284215 | http://purl.uniprot.org/core/author | "Van Veldhuizen P.J."xsd:string |
| http://purl.uniprot.org/citations/18284215 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18284215 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/18284215 | http://purl.uniprot.org/core/pages | "3345-3351"xsd:string |
| http://purl.uniprot.org/citations/18284215 | http://purl.uniprot.org/core/title | "VEGF-A165 induces human aortic smooth muscle cell migration by activating neuropilin-1-VEGFR1-PI3K axis."xsd:string |
| http://purl.uniprot.org/citations/18284215 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/18284215 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18284215 |
| http://purl.uniprot.org/citations/18284215 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18284215 |
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| http://purl.uniprot.org/uniprot/#_A0A0Y0IMM4-mappedCitation-18284215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18284215 |
| http://purl.uniprot.org/uniprot/#_A0A0Y0J542-mappedCitation-18284215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18284215 |
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| http://purl.uniprot.org/uniprot/#_A8K9V7-mappedCitation-18284215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18284215 |