| http://purl.uniprot.org/citations/18287027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18287027 | http://www.w3.org/2000/01/rdf-schema#comment | "We examined the sera of six patients before and after i.v. infusions of autologous chronic lymphocytic leukemia (CLL) cells transduced ex vivo with an adenovirus encoding CD154 (Ad-CD154). Five patients made high-titer antibodies against adenovirus and three made IgG reactive with a leukemia-associated surface antigen, which we identified as ROR1. Anti-ROR1 antibodies were not detected in the sera of untreated patients. We generated anti-ROR1 mAbs and found they reacted specifically with the CLL cells of all patients, but not with nonleukemic leukocytes, a wide variety of normal adult tissues, or blood mononuclear cells, including CD5(+) B cells of healthy adults. ROR1 could bind Wnt5a, which induced activation of NF-kappaB when coexpressed with ROR1 in HEK293 cells and enhanced the survival of CLL cells in vitro, an effect that could be neutralized by posttreatment anti-ROR1 antisera. We conclude that patients with CLL can break immune tolerance to ROR1, which is an oncofetal surface antigen and survival-signaling receptor in this neoplastic disease."xsd:string |
| http://purl.uniprot.org/citations/18287027 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0712148105"xsd:string |
| http://purl.uniprot.org/citations/18287027 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/18287027 | http://purl.uniprot.org/core/author | "Endo T."xsd:string |
| http://purl.uniprot.org/citations/18287027 | http://purl.uniprot.org/core/author | "Fukuda T."xsd:string |
| http://purl.uniprot.org/citations/18287027 | http://purl.uniprot.org/core/author | "Lu D."xsd:string |
| http://purl.uniprot.org/citations/18287027 | http://purl.uniprot.org/core/author | "Tang L."xsd:string |
| http://purl.uniprot.org/citations/18287027 | http://purl.uniprot.org/core/author | "Carson D.A."xsd:string |
| http://purl.uniprot.org/citations/18287027 | http://purl.uniprot.org/core/author | "Kipps T.J."xsd:string |
| http://purl.uniprot.org/citations/18287027 | http://purl.uniprot.org/core/author | "Rassenti L.Z."xsd:string |
| http://purl.uniprot.org/citations/18287027 | http://purl.uniprot.org/core/author | "Prussak C.E."xsd:string |
| http://purl.uniprot.org/citations/18287027 | http://purl.uniprot.org/core/author | "Castro J.E."xsd:string |
| http://purl.uniprot.org/citations/18287027 | http://purl.uniprot.org/core/author | "Widhopf G.F."xsd:string |
| http://purl.uniprot.org/citations/18287027 | http://purl.uniprot.org/core/author | "Cantwell M.J."xsd:string |
| http://purl.uniprot.org/citations/18287027 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18287027 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/18287027 | http://purl.uniprot.org/core/pages | "3047-3052"xsd:string |
| http://purl.uniprot.org/citations/18287027 | http://purl.uniprot.org/core/title | "Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a."xsd:string |
| http://purl.uniprot.org/citations/18287027 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/18287027 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18287027 |
| http://purl.uniprot.org/citations/18287027 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18287027 |
| http://purl.uniprot.org/uniprot/Q01973#attribution-0727954D987ACCCBEEED06E61592E9DE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18287027 |
| http://purl.uniprot.org/uniprot/P41221#attribution-0727954D987ACCCBEEED06E61592E9DE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18287027 |
| http://purl.uniprot.org/uniprot/P41221#attribution-FCBE003147304BE0155A3A29A3E7963A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18287027 |