| http://purl.uniprot.org/citations/18287044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18287044 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18287044 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanism by which the Carma1-Bcl10-MALT1 (CBM) complex couples T cell antigen receptor (TCR) signaling to IkappaB kinase (IKK) and NF-kappaB activation is not known. Here, we show that Bcl10 undergoes K63-linked polyubiquitination in response to T cell activation and subsequently binds NEMO, the regulatory subunit of IKK. This interaction requires the ubiquitin-binding activity of NEMO. The sites of Bcl10 ubiquitination were mapped to K31 and K63. Mutation of these residues did not affect TCR signaling-induced CBM complex assembly but prevented Bcl10 ubiquitination, NEMO binding, and NF-kappaB activation. Therefore, the regulated ubiquitination of Bcl10 and its recognition by NEMO are a critical link between the CBM complex, IKK recruitment, and NF-kappaB activation."xsd:string |
| http://purl.uniprot.org/citations/18287044 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0712313105"xsd:string |
| http://purl.uniprot.org/citations/18287044 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0712313105"xsd:string |
| http://purl.uniprot.org/citations/18287044 | http://purl.uniprot.org/core/author | "Wu C.J."xsd:string |
| http://purl.uniprot.org/citations/18287044 | http://purl.uniprot.org/core/author | "Wu C.J."xsd:string |
| http://purl.uniprot.org/citations/18287044 | http://purl.uniprot.org/core/author | "Ashwell J.D."xsd:string |
| http://purl.uniprot.org/citations/18287044 | http://purl.uniprot.org/core/author | "Ashwell J.D."xsd:string |
| http://purl.uniprot.org/citations/18287044 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18287044 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18287044 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/18287044 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/18287044 | http://purl.uniprot.org/core/pages | "3023-3028"xsd:string |
| http://purl.uniprot.org/citations/18287044 | http://purl.uniprot.org/core/pages | "3023-3028"xsd:string |
| http://purl.uniprot.org/citations/18287044 | http://purl.uniprot.org/core/title | "NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation."xsd:string |
| http://purl.uniprot.org/citations/18287044 | http://purl.uniprot.org/core/title | "NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation."xsd:string |
| http://purl.uniprot.org/citations/18287044 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/18287044 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/18287044 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18287044 |
| http://purl.uniprot.org/citations/18287044 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18287044 |
| http://purl.uniprot.org/citations/18287044 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18287044 |
| http://purl.uniprot.org/citations/18287044 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18287044 |
| http://purl.uniprot.org/uniprot/Q9Y6K9 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/18287044 |
| http://purl.uniprot.org/uniprot/O95999 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/18287044 |