| http://purl.uniprot.org/citations/18287876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18287876 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic inflammation induced by Helicobacter pylori is a key process in gastric carcinogenesis. We hypothesized that genetic polymorphisms in important mediators of H. pylori-induced inflammation may influence the risk of developing various grades of precancerous lesions. We studied the associations between single nucleotide polymorphisms (SNPs) in cyclooxygenase 1 and 2 (PTGS1 and PTGS2), inducible nitric oxide synthase (NOS2A), interferon gamma (IFNG) and its receptor (IFNGR1), and risk of gastric precancerous lesions in a Venezuelan population characterized by high rates of H. pylori infection. We found no association of precancerous lesions with SNPs in PTGS1 and in IFNG. A nonsynonymous SNP of NOS2A (Ser608Leu) and an SNP located in the promoter of IFNGR1 (C-56T) were associated with higher risk of atrophic gastritis [odds ratio (OR)=1.37, 95% confidence interval (CI)=1.01-1.86, and OR=1.49, 95% CI=1.01-2.19, respectively]. Two SNPs of PTGS2 were associated with risk of dysplasia (OR=1.60, 95% CI=1.01-2.54, and OR=0.66, 95% CI=0.43-0.99). We conclude that genetic variability in the genes we studied does not play a major role in the early stages of gastric carcinogenesis."xsd:string |
| http://purl.uniprot.org/citations/18287876 | http://purl.org/dc/terms/identifier | "doi:10.1097/cej.0b013e3282b6fd88"xsd:string |
| http://purl.uniprot.org/citations/18287876 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/18287876 | http://purl.uniprot.org/core/author | "Lopez G."xsd:string |
| http://purl.uniprot.org/citations/18287876 | http://purl.uniprot.org/core/author | "Kato I."xsd:string |
| http://purl.uniprot.org/citations/18287876 | http://purl.uniprot.org/core/author | "van Doorn L.J."xsd:string |
| http://purl.uniprot.org/citations/18287876 | http://purl.uniprot.org/core/author | "Canzian F."xsd:string |
| http://purl.uniprot.org/citations/18287876 | http://purl.uniprot.org/core/author | "Munoz N."xsd:string |
| http://purl.uniprot.org/citations/18287876 | http://purl.uniprot.org/core/author | "Schwartz A.G."xsd:string |
| http://purl.uniprot.org/citations/18287876 | http://purl.uniprot.org/core/author | "Plummer M."xsd:string |
| http://purl.uniprot.org/citations/18287876 | http://purl.uniprot.org/core/author | "Franceschi S."xsd:string |
| http://purl.uniprot.org/citations/18287876 | http://purl.uniprot.org/core/author | "Gioia-Patricola L."xsd:string |
| http://purl.uniprot.org/citations/18287876 | http://purl.uniprot.org/core/author | "Severson R.K."xsd:string |
| http://purl.uniprot.org/citations/18287876 | http://purl.uniprot.org/core/author | "Vivas J."xsd:string |
| http://purl.uniprot.org/citations/18287876 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18287876 | http://purl.uniprot.org/core/name | "Eur J Cancer Prev"xsd:string |
| http://purl.uniprot.org/citations/18287876 | http://purl.uniprot.org/core/pages | "178-183"xsd:string |
| http://purl.uniprot.org/citations/18287876 | http://purl.uniprot.org/core/title | "Genetic polymorphisms in mediators of inflammation and gastric precancerous lesions."xsd:string |
| http://purl.uniprot.org/citations/18287876 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/18287876 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18287876 |
| http://purl.uniprot.org/citations/18287876 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18287876 |
| http://purl.uniprot.org/uniprot/#_D9MWI3-mappedCitation-18287876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18287876 |
| http://purl.uniprot.org/uniprot/#_A0A087X296-mappedCitation-18287876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18287876 |
| http://purl.uniprot.org/uniprot/#_P15260-mappedCitation-18287876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18287876 |