| http://purl.uniprot.org/citations/18288455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18288455 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo investigate whether glutamine supplementation modulates intestinal nuclear factor kappa B (NF-kappaB) activity and pro-inflammatory cytokine expression after traumatic brain injury (TBI) in rats.Materials and methodsRight parietal cortical contusion in male rats was made by the weight-dropping method. After trauma, the rats were randomly given chow alone or glutamine mixed chow for 5 d. Gut samples were extracted at 5 d postinjury. We measured NF-kappaB binding activity by electrophoretic mobility shift assay; NF-kappaB subunits p50 and p65 expression by immunohistochemistry; the concentrations of interleukin-1beta, tumor necrosis factor-alpha and interleukin-6 by enzyme-linked immunosorbent assay; intestinal mucosal morphological changes by histopathological study and electron microscopy; and apoptosis by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining.ResultsAdministration of glutamine following TBI could decrease NF-kappaB binding activity, NF-kappaB p65 protein expression and concentrations of pro-inflammatory cytokines in the gut. TBI-induced damage of gut structure was ameliorated after glutamine supplementation.ConclusionThe results of the present study suggest that the therapeutic benefit of post-TBI glutamine supplementation might be due to its inhibitory effects on intestinal NF-kappaB activation and pro-inflammatory cytokine expression."xsd:string |
| http://purl.uniprot.org/citations/18288455 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00011-007-7101-7"xsd:string |
| http://purl.uniprot.org/citations/18288455 | http://purl.uniprot.org/core/author | "Chen G."xsd:string |
| http://purl.uniprot.org/citations/18288455 | http://purl.uniprot.org/core/author | "Shi J."xsd:string |
| http://purl.uniprot.org/citations/18288455 | http://purl.uniprot.org/core/author | "Qi M."xsd:string |
| http://purl.uniprot.org/citations/18288455 | http://purl.uniprot.org/core/author | "Yin H."xsd:string |
| http://purl.uniprot.org/citations/18288455 | http://purl.uniprot.org/core/author | "Hang C."xsd:string |
| http://purl.uniprot.org/citations/18288455 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18288455 | http://purl.uniprot.org/core/name | "Inflamm Res"xsd:string |
| http://purl.uniprot.org/citations/18288455 | http://purl.uniprot.org/core/pages | "57-64"xsd:string |
| http://purl.uniprot.org/citations/18288455 | http://purl.uniprot.org/core/title | "Glutamine decreases intestinal nuclear factor kappa B activity and pro-inflammatory cytokine expression after traumatic brain injury in rats."xsd:string |
| http://purl.uniprot.org/citations/18288455 | http://purl.uniprot.org/core/volume | "57"xsd:string |
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