| http://purl.uniprot.org/citations/18288583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18288583 | http://www.w3.org/2000/01/rdf-schema#comment | "The gene trap technique is a powerful approach for characterizing and mutating genes in the mouse. We used this method to identify a mouse gene of unknown function and to establish a mutant mouse line. We subsequently identified one gene, denoted Ayu17-449, on mouse chromosome 3 that comprised 14 exons encoding 1920 amino acids with a granin motif in its N-terminal sequence. In adult mice, this gene was highly expressed in the brain, heart, lung, muscle, stomach, and kidney. The insertion of a trap vector into the second intron of this gene resulted in the null mutation. Homozygous mice for these mutation died by 1 day after birth. Mutant mice showed a loss of acidic granules in the proximal convoluted tubules of the kidney. Our data demonstrates that Ayu17-449 is important for mouse survival."xsd:string |
| http://purl.uniprot.org/citations/18288583 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11248-008-9170-y"xsd:string |
| http://purl.uniprot.org/citations/18288583 | http://purl.uniprot.org/core/author | "Araki K."xsd:string |
| http://purl.uniprot.org/citations/18288583 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/18288583 | http://purl.uniprot.org/core/author | "Tang H."xsd:string |
| http://purl.uniprot.org/citations/18288583 | http://purl.uniprot.org/core/author | "Yamamura K."xsd:string |
| http://purl.uniprot.org/citations/18288583 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18288583 | http://purl.uniprot.org/core/name | "Transgenic Res"xsd:string |
| http://purl.uniprot.org/citations/18288583 | http://purl.uniprot.org/core/pages | "599-608"xsd:string |
| http://purl.uniprot.org/citations/18288583 | http://purl.uniprot.org/core/title | "Characterization of Ayu17-449 gene expression and resultant kidney pathology in a knockout mouse model."xsd:string |
| http://purl.uniprot.org/citations/18288583 | http://purl.uniprot.org/core/volume | "17"xsd:string |
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