| http://purl.uniprot.org/citations/18292537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18292537 | http://www.w3.org/2000/01/rdf-schema#comment | "Initiation of diabetes in NOD mice can be mediated by the costimulatory signals received by T cells. The ICOS is found on Ag-experienced T cells where it acts as a potent regulator of T cell responses. To determine the function of ICOS in diabetes, we followed the course of autoimmune disease and examined T cells in ICOS-deficient NOD mice. The presence of ICOS was indispensable for the development of insulitis and hyperglycemia in NOD mice. In T cells, the deletion of ICOS resulted in a decreased production of the Th1 cytokine IFN-gamma, whereas the numbers of regulatory T cells remained unchanged. We conclude that ICOS is critically important for the induction of the autoimmune process that leads to diabetes."xsd:string |
| http://purl.uniprot.org/citations/18292537 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.180.5.3140"xsd:string |
| http://purl.uniprot.org/citations/18292537 | http://purl.uniprot.org/core/author | "Booth C.J."xsd:string |
| http://purl.uniprot.org/citations/18292537 | http://purl.uniprot.org/core/author | "Flavell R.A."xsd:string |
| http://purl.uniprot.org/citations/18292537 | http://purl.uniprot.org/core/author | "Du W."xsd:string |
| http://purl.uniprot.org/citations/18292537 | http://purl.uniprot.org/core/author | "Dong C."xsd:string |
| http://purl.uniprot.org/citations/18292537 | http://purl.uniprot.org/core/author | "Wen L."xsd:string |
| http://purl.uniprot.org/citations/18292537 | http://purl.uniprot.org/core/author | "Tran E."xsd:string |
| http://purl.uniprot.org/citations/18292537 | http://purl.uniprot.org/core/author | "Hawiger D."xsd:string |
| http://purl.uniprot.org/citations/18292537 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18292537 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18292537 | http://purl.uniprot.org/core/pages | "3140-3147"xsd:string |
| http://purl.uniprot.org/citations/18292537 | http://purl.uniprot.org/core/title | "ICOS mediates the development of insulin-dependent diabetes mellitus in nonobese diabetic mice."xsd:string |
| http://purl.uniprot.org/citations/18292537 | http://purl.uniprot.org/core/volume | "180"xsd:string |
| http://purl.uniprot.org/citations/18292537 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18292537 |
| http://purl.uniprot.org/citations/18292537 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18292537 |
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