| http://purl.uniprot.org/citations/18292556 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18292556 | http://www.w3.org/2000/01/rdf-schema#comment | "Properdin is a positive regulator of complement activation so far known to be instrumental in the survival of infections with certain serotypes of Neisseria meningitidis. We have generated a fully backcrossed properdin-deficient mouse line by conventional gene-specific targeting. In vitro, properdin-deficient serum is impaired in alternative pathway-dependent generation of complement fragment C3b when activated by Escherichia coli DH5alpha. Properdin-deficient mice and wild-type littermates compare in their levels of C3 and IgM. In an in vivo model of polymicrobial septic peritonitis induced by sublethal cecal ligation and puncture, properdin-deficient mice appear immunocompromised, because they are significantly impaired in their survival compared with wild-type littermates. We further show that properdin localizes to mast cells and that properdin has the ability to directly associate with E. coli DH5alpha. We conclude that properdin plays a significant role in the outcome of polymicrobial sepsis."xsd:string |
| http://purl.uniprot.org/citations/18292556 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.180.5.3313"xsd:string |
| http://purl.uniprot.org/citations/18292556 | http://purl.uniprot.org/core/author | "Brown J."xsd:string |
| http://purl.uniprot.org/citations/18292556 | http://purl.uniprot.org/core/author | "Schwaeble W.J."xsd:string |
| http://purl.uniprot.org/citations/18292556 | http://purl.uniprot.org/core/author | "Echtenacher B."xsd:string |
| http://purl.uniprot.org/citations/18292556 | http://purl.uniprot.org/core/author | "Dupont A."xsd:string |
| http://purl.uniprot.org/citations/18292556 | http://purl.uniprot.org/core/author | "Stover C.M."xsd:string |
| http://purl.uniprot.org/citations/18292556 | http://purl.uniprot.org/core/author | "Mannel D.N."xsd:string |
| http://purl.uniprot.org/citations/18292556 | http://purl.uniprot.org/core/author | "Luckett J.C."xsd:string |
| http://purl.uniprot.org/citations/18292556 | http://purl.uniprot.org/core/author | "Figgitt S.E."xsd:string |
| http://purl.uniprot.org/citations/18292556 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18292556 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18292556 | http://purl.uniprot.org/core/pages | "3313-3318"xsd:string |
| http://purl.uniprot.org/citations/18292556 | http://purl.uniprot.org/core/title | "Properdin plays a protective role in polymicrobial septic peritonitis."xsd:string |
| http://purl.uniprot.org/citations/18292556 | http://purl.uniprot.org/core/volume | "180"xsd:string |
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