| http://purl.uniprot.org/citations/18292755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18292755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18292755 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the gene autoimmune regulator (AIRE) cause autoimmune polyendocrinopathy candidiasis ectodermal dystrophy. AIRE is expressed in thymic medullary epithelial cells, where it promotes the expression of tissue-restricted antigens. By the combined use of biochemical and biophysical methods, we show that AIRE selectively interacts with histone H3 through its first plant homeodomain (PHD) finger (AIRE-PHD1) and preferentially binds to non-methylated H3K4 (H3K4me0). Accordingly, in vivo AIRE binds to and activates promoters containing low levels of H3K4me3 in human embryonic kidney 293 cells. We conclude that AIRE-PHD1 is an important member of a newly identified class of PHD fingers that specifically recognize H3K4me0, thus providing a new link between the status of histone modifications and the regulation of tissue-restricted antigen expression in thymus."xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.embor.2008.11"xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.embor.2008.11"xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.uniprot.org/core/author | "Bottomley M.J."xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.uniprot.org/core/author | "Bottomley M.J."xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.uniprot.org/core/author | "Gaetani M."xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.uniprot.org/core/author | "Gaetani M."xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.uniprot.org/core/author | "Chignola F."xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.uniprot.org/core/author | "Chignola F."xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.uniprot.org/core/author | "Hetenyi C."xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.uniprot.org/core/author | "Hetenyi C."xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.uniprot.org/core/author | "Liiv I."xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.uniprot.org/core/author | "Liiv I."xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.uniprot.org/core/author | "Maran U."xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.uniprot.org/core/author | "Maran U."xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.uniprot.org/core/author | "Mollica L."xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.uniprot.org/core/author | "Mollica L."xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.uniprot.org/core/author | "Musco G."xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.uniprot.org/core/author | "Musco G."xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.uniprot.org/core/author | "Org T."xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.uniprot.org/core/author | "Org T."xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.uniprot.org/core/author | "Peterson P."xsd:string |
| http://purl.uniprot.org/citations/18292755 | http://purl.uniprot.org/core/author | "Peterson P."xsd:string |