| http://purl.uniprot.org/citations/18292964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18292964 | http://www.w3.org/2000/01/rdf-schema#comment | "Synphilin-1 has been linked to Parkinson's disease (PD) based on its role as an alpha-synuclein (PARK1) and Parkin (PARK2) interacting protein and its presence in lewy bodies in brains of PD patients. We recently identified a R621C mutation in the synphilin-1 gene in German PD patients. Functional analyses revealed that mutant synphilin-1 increases cellular stress, however, the involved molecular signalling pathways are currently unknown. Using microarray based gene expression analysis of dopaminergic SH-SY5Y cells overexpressing wild type or R621C mutant synphilin-1 we investigated differentially regulated genes and signalling networks using the Ingenuity Pathways Analysis tool. We show specific effects of C621 mutant synphilin-1 on gene expression that correlate with its role as a susceptibility factor in PD. The most significantly regulated signalling network was defined by the tumor growth factor beta 1 (TGF-beta1) suggesting an involvement of synphilin-1 in TGF-beta mediated signalling pathways modulating the cellular stress response."xsd:string |
| http://purl.uniprot.org/citations/18292964 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00702-008-0031-x"xsd:string |
| http://purl.uniprot.org/citations/18292964 | http://purl.uniprot.org/core/author | "Riess O."xsd:string |
| http://purl.uniprot.org/citations/18292964 | http://purl.uniprot.org/core/author | "Kruger R."xsd:string |
| http://purl.uniprot.org/citations/18292964 | http://purl.uniprot.org/core/author | "Bonin M."xsd:string |
| http://purl.uniprot.org/citations/18292964 | http://purl.uniprot.org/core/author | "Kautzmann S."xsd:string |
| http://purl.uniprot.org/citations/18292964 | http://purl.uniprot.org/core/author | "Marx F.P."xsd:string |
| http://purl.uniprot.org/citations/18292964 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18292964 | http://purl.uniprot.org/core/name | "J Neural Transm (Vienna)"xsd:string |
| http://purl.uniprot.org/citations/18292964 | http://purl.uniprot.org/core/pages | "941-958"xsd:string |
| http://purl.uniprot.org/citations/18292964 | http://purl.uniprot.org/core/title | "Microarray expression analysis reveals genetic pathways implicated in C621 synphilin-1-mediated toxicity."xsd:string |
| http://purl.uniprot.org/citations/18292964 | http://purl.uniprot.org/core/volume | "115"xsd:string |
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