| http://purl.uniprot.org/citations/18294141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18294141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18294141 | http://www.w3.org/2000/01/rdf-schema#comment | "The present study demonstrates different functional domains of a recently described centrosomal protein, Cep57 (centrosomal protein 57). Endogenous Cep57 protein and ectopic expression of full-length protein or the N-terminal coiled-coil domain localize to the centrosome internal to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component. The N-terminus can also multimerize with the N-terminus of other Cep57 molecules. The C-terminus contains a second coiled-coil domain that directly binds to MTs (microtubules). This domain both nucleates and bundles MTs in vitro. This activity was also seen in vivo, as overexpression of full-length Cep57 or the C-terminus generates nocodazole-resistant MT cables in cells. Based on the present findings, we propose that Cep57 serves as a link with its N-terminus anchored to the centriole or centromatrix and its C-terminus to MTs."xsd:string |
| http://purl.uniprot.org/citations/18294141 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20071501"xsd:string |
| http://purl.uniprot.org/citations/18294141 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20071501"xsd:string |
| http://purl.uniprot.org/citations/18294141 | http://purl.uniprot.org/core/author | "Miyake T."xsd:string |
| http://purl.uniprot.org/citations/18294141 | http://purl.uniprot.org/core/author | "Miyake T."xsd:string |
| http://purl.uniprot.org/citations/18294141 | http://purl.uniprot.org/core/author | "Stukenberg P.T."xsd:string |
| http://purl.uniprot.org/citations/18294141 | http://purl.uniprot.org/core/author | "Stukenberg P.T."xsd:string |
| http://purl.uniprot.org/citations/18294141 | http://purl.uniprot.org/core/author | "Khromov A.S."xsd:string |
| http://purl.uniprot.org/citations/18294141 | http://purl.uniprot.org/core/author | "Khromov A.S."xsd:string |
| http://purl.uniprot.org/citations/18294141 | http://purl.uniprot.org/core/author | "Momotani K."xsd:string |
| http://purl.uniprot.org/citations/18294141 | http://purl.uniprot.org/core/author | "Momotani K."xsd:string |
| http://purl.uniprot.org/citations/18294141 | http://purl.uniprot.org/core/author | "Somlyo A.V."xsd:string |
| http://purl.uniprot.org/citations/18294141 | http://purl.uniprot.org/core/author | "Somlyo A.V."xsd:string |
| http://purl.uniprot.org/citations/18294141 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18294141 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18294141 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/18294141 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/18294141 | http://purl.uniprot.org/core/pages | "265-273"xsd:string |
| http://purl.uniprot.org/citations/18294141 | http://purl.uniprot.org/core/pages | "265-273"xsd:string |
| http://purl.uniprot.org/citations/18294141 | http://purl.uniprot.org/core/title | "Cep57, a multidomain protein with unique microtubule and centrosomal localization domains."xsd:string |
| http://purl.uniprot.org/citations/18294141 | http://purl.uniprot.org/core/title | "Cep57, a multidomain protein with unique microtubule and centrosomal localization domains."xsd:string |
| http://purl.uniprot.org/citations/18294141 | http://purl.uniprot.org/core/volume | "412"xsd:string |
| http://purl.uniprot.org/citations/18294141 | http://purl.uniprot.org/core/volume | "412"xsd:string |