| http://purl.uniprot.org/citations/18299274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18299274 | http://www.w3.org/2000/01/rdf-schema#comment | "Two types of functional interleukin-2 receptor (IL-2Ralpha/IL-2Rbeta/gammac and IL-2Rbeta/gammac) have already been characterized in humans. Here we describe a new form consisting of IL-2Rbeta/beta homodimers that assemble spontaneously in the absence of gammac. Co-transfection of COS-7 cells with constructs expressing IL-2Rbeta chains tagged with either HA or MYC sequences results in the formation of IL-2Rbeta:HA/IL-2Rbeta:MYC complexes detectable by coimmunoprecipitation. The formation of these IL-2Rbeta:HA/IL-2Rbeta:MYC dimers is also observed in the absence of IL-2. Moreover, in COS cells expressing chimeras of IL-2Rbeta fused to fluorescence reporters such as IL-2Rbeta:ECFP and IL-2Rbeta:EYFP, we also observed specific FRET at the surface of living cells, as expected for dimer formation. Transiently transfected COS-7 cells expressing IL-2Rbeta bind 125I-labeled IL-2 (homodimers, Kd = 1nM) as cells expressing both IL-2Rbeta and gammac chains (heterodimers, Kd = 1 nM). IL-2Rbeta/IL-2Rbeta could represent either a decoy receptor or a new form of IL-2R involved in signaling when gammac expression is low."xsd:string |
| http://purl.uniprot.org/citations/18299274 | http://purl.org/dc/terms/identifier | "doi:10.1684/ecn.2008.0120"xsd:string |
| http://purl.uniprot.org/citations/18299274 | http://purl.uniprot.org/core/author | "Rose T."xsd:string |
| http://purl.uniprot.org/citations/18299274 | http://purl.uniprot.org/core/author | "Chastagner P."xsd:string |
| http://purl.uniprot.org/citations/18299274 | http://purl.uniprot.org/core/author | "Moreau J.L."xsd:string |
| http://purl.uniprot.org/citations/18299274 | http://purl.uniprot.org/core/author | "Gesbert F."xsd:string |
| http://purl.uniprot.org/citations/18299274 | http://purl.uniprot.org/core/author | "Theze J."xsd:string |
| http://purl.uniprot.org/citations/18299274 | http://purl.uniprot.org/core/author | "Colle J.H."xsd:string |
| http://purl.uniprot.org/citations/18299274 | http://purl.uniprot.org/core/author | "Juffroy O."xsd:string |
| http://purl.uniprot.org/citations/18299274 | http://purl.uniprot.org/core/author | "Mazard-Pasquier V."xsd:string |
| http://purl.uniprot.org/citations/18299274 | http://purl.uniprot.org/core/author | "Pillet A.H."xsd:string |
| http://purl.uniprot.org/citations/18299274 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18299274 | http://purl.uniprot.org/core/name | "Eur Cytokine Netw"xsd:string |
| http://purl.uniprot.org/citations/18299274 | http://purl.uniprot.org/core/pages | "49-59"xsd:string |
| http://purl.uniprot.org/citations/18299274 | http://purl.uniprot.org/core/title | "Human IL-Rbeta chains form IL-2 binding homodimers."xsd:string |
| http://purl.uniprot.org/citations/18299274 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/18299274 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18299274 |
| http://purl.uniprot.org/citations/18299274 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18299274 |
| http://purl.uniprot.org/uniprot/#_Q13169-mappedCitation-18299274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18299274 |
| http://purl.uniprot.org/uniprot/#_Q71V48-mappedCitation-18299274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18299274 |
| http://purl.uniprot.org/uniprot/#_P14784-mappedCitation-18299274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18299274 |
| http://purl.uniprot.org/uniprot/#_Q6QWN0-mappedCitation-18299274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18299274 |
| http://purl.uniprot.org/uniprot/#_Q16334-mappedCitation-18299274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18299274 |
| http://purl.uniprot.org/uniprot/#_O95974-mappedCitation-18299274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18299274 |