| http://purl.uniprot.org/citations/18299344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18299344 | http://www.w3.org/2000/01/rdf-schema#comment | "FOXO is thought to function as a repressor of growth that is, in turn, inhibited by insulin signaling. However, inactivating mutations in Drosophila melanogaster FOXO result in viable flies of normal size, which raises a question over the involvement of FOXO in growth regulation. Previously, a growth-suppressive role for FOXO under conditions of increased target of rapamycin (TOR) pathway activity was described. Here, we further characterize this phenomenon. We show that tuberous sclerosis complex 1 mutations cause increased FOXO levels, resulting in elevated expression of FOXO-regulated genes, some of which are known to antagonize growth-promoting pathways. Analogous transcriptional changes are observed in mammalian cells, which implies that FOXO attenuates TOR-driven growth in diverse species."xsd:string |
| http://purl.uniprot.org/citations/18299344 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200710100"xsd:string |
| http://purl.uniprot.org/citations/18299344 | http://purl.uniprot.org/core/author | "Puig O."xsd:string |
| http://purl.uniprot.org/citations/18299344 | http://purl.uniprot.org/core/author | "Hariharan I.K."xsd:string |
| http://purl.uniprot.org/citations/18299344 | http://purl.uniprot.org/core/author | "Harvey K.F."xsd:string |
| http://purl.uniprot.org/citations/18299344 | http://purl.uniprot.org/core/author | "Ellisen L.W."xsd:string |
| http://purl.uniprot.org/citations/18299344 | http://purl.uniprot.org/core/author | "Sofer A."xsd:string |
| http://purl.uniprot.org/citations/18299344 | http://purl.uniprot.org/core/author | "Mattila J."xsd:string |
| http://purl.uniprot.org/citations/18299344 | http://purl.uniprot.org/core/author | "Ramsey M.R."xsd:string |
| http://purl.uniprot.org/citations/18299344 | http://purl.uniprot.org/core/author | "Bennett F.C."xsd:string |
| http://purl.uniprot.org/citations/18299344 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18299344 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/18299344 | http://purl.uniprot.org/core/pages | "691-696"xsd:string |
| http://purl.uniprot.org/citations/18299344 | http://purl.uniprot.org/core/title | "FOXO-regulated transcription restricts overgrowth of Tsc mutant organs."xsd:string |
| http://purl.uniprot.org/citations/18299344 | http://purl.uniprot.org/core/volume | "180"xsd:string |
| http://purl.uniprot.org/citations/18299344 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18299344 |
| http://purl.uniprot.org/citations/18299344 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18299344 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFJ2-mappedCitation-18299344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18299344 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHI3-mappedCitation-18299344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18299344 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LIX2-mappedCitation-18299344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18299344 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGN1-mappedCitation-18299344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18299344 |
| http://purl.uniprot.org/uniprot/#_A0A126GUT4-mappedCitation-18299344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18299344 |
| http://purl.uniprot.org/uniprot/#_A4V3G1-mappedCitation-18299344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18299344 |
| http://purl.uniprot.org/uniprot/#_B7Z0S3-mappedCitation-18299344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18299344 |