| http://purl.uniprot.org/citations/18302937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18302937 | http://www.w3.org/2000/01/rdf-schema#comment | "delta-Catenin is upregulated in human carcinomas. However, little is known about the potential transcriptional factors that regulate delta-catenin expression in cancer. Using a human delta-catenin reporter system, we have screened several nuclear signaling modulators to test whether they can affect delta-catenin transcription. Among beta-catenin/LEF-1, Notch1, and E2F1, E2F1 dramatically increased delta-catenin-luciferase activities while beta-catenin/LEF-1 induced only a marginal increase. Rb suppressed the upregulation of delta-catenin-luciferase activities induced by E2F1 but did not interact with delta-catenin. RT-PCR and Western blot analyses in 4 different prostate cancer cell lines revealed that regulation of delta-catenin expression is controlled mainly at the transcriptional level. Interestingly, the effects of E2F1 on delta-catenin expression were observed only in human cancer cells expressing abundant endogenous delta-catenin. These studies identify E2F1 as a positive transcriptional regulator for delta-catenin, but further suggest the presence of strong negative regulator(s) for delta-catenin in prostate cancer cells with minimal endogenous delta-catenin expression."xsd:string |
| http://purl.uniprot.org/citations/18302937 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2008.02.069"xsd:string |
| http://purl.uniprot.org/citations/18302937 | http://purl.uniprot.org/core/author | "Kim K."xsd:string |
| http://purl.uniprot.org/citations/18302937 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/18302937 | http://purl.uniprot.org/core/author | "Lu Q."xsd:string |
| http://purl.uniprot.org/citations/18302937 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/18302937 | http://purl.uniprot.org/core/author | "Oh M."xsd:string |
| http://purl.uniprot.org/citations/18302937 | http://purl.uniprot.org/core/author | "Ki H."xsd:string |
| http://purl.uniprot.org/citations/18302937 | http://purl.uniprot.org/core/author | "Bareiss S."xsd:string |
| http://purl.uniprot.org/citations/18302937 | http://purl.uniprot.org/core/author | "Fini M.E."xsd:string |
| http://purl.uniprot.org/citations/18302937 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18302937 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/18302937 | http://purl.uniprot.org/core/pages | "414-420"xsd:string |
| http://purl.uniprot.org/citations/18302937 | http://purl.uniprot.org/core/title | "Identification of E2F1 as a positive transcriptional regulator for delta-catenin."xsd:string |
| http://purl.uniprot.org/citations/18302937 | http://purl.uniprot.org/core/volume | "369"xsd:string |
| http://purl.uniprot.org/citations/18302937 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18302937 |
| http://purl.uniprot.org/citations/18302937 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18302937 |
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| http://purl.uniprot.org/uniprot/#_Q01094-mappedCitation-18302937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18302937 |