| http://purl.uniprot.org/citations/18302939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18302939 | http://www.w3.org/2000/01/rdf-schema#comment | "Galectin-1 and galectin-3 are the most ubiquitously expressed members of the galectin family and more importantly, these two molecules are shown to have opposite effects on pro-inflammatory responses and/or apoptosis depending on the cell type. Herein, we demonstrate for the first time that galectin-3 induces mast cell apoptosis. Mast cells expressed substantial levels of galectin-3 and galectin-1 and to a lesser extent the receptor for advanced glycation end products (RAGE) on their surfaces. Treatment of cells with galectin-3 at concentrations of > or =100 nM for 18-44 h resulted in cell death by apoptosis. Galectin-3-induced apoptosis was completely prevented by lactose, neutralizing antibody to RAGE, and the caspase-3 inhibitor z-DEVD-fmk. Galectin-3-induced apoptosis was also completely abolished by dithiothreitol and superoxide dismutase, but not inhibited by catalase. Moreover, galectin-3 but not galectin-1 induced the release of superoxide, which was blocked by lactose, anti-RAGE, and dithiothreitol. Finally, galectin-3-induced apoptosis was blocked by bongkrekic acid, an antagonist of the mitochondrial permeability transition pore (PTP), while atractyloside, an agonist of the PTP, greatly facilitated galectin-1-induced apoptosis. These data suggest that galectin-3 induces oxidative stress, PTP opening, and the caspase-dependent death pathway by binding to putative surface receptors including RAGE via the carbohydrate recognition domain."xsd:string |
| http://purl.uniprot.org/citations/18302939 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2008.01.025"xsd:string |
| http://purl.uniprot.org/citations/18302939 | http://purl.uniprot.org/core/author | "Inoue T."xsd:string |
| http://purl.uniprot.org/citations/18302939 | http://purl.uniprot.org/core/author | "Suzuki Y."xsd:string |
| http://purl.uniprot.org/citations/18302939 | http://purl.uniprot.org/core/author | "Yoshimaru T."xsd:string |
| http://purl.uniprot.org/citations/18302939 | http://purl.uniprot.org/core/author | "Ra C."xsd:string |
| http://purl.uniprot.org/citations/18302939 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18302939 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/18302939 | http://purl.uniprot.org/core/pages | "924-934"xsd:string |
| http://purl.uniprot.org/citations/18302939 | http://purl.uniprot.org/core/title | "Galectin-3 but not galectin-1 induces mast cell death by oxidative stress and mitochondrial permeability transition."xsd:string |
| http://purl.uniprot.org/citations/18302939 | http://purl.uniprot.org/core/volume | "1783"xsd:string |
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