| http://purl.uniprot.org/citations/18303018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18303018 | http://www.w3.org/2000/01/rdf-schema#comment | "SCUBE1 (signal peptide-CUB-EGF domain-containing protein 1) is a novel, secreted, cell surface glycoprotein expressed during early embryogenesis and found in platelet and endothelial cells. This protein is composed of an N-terminal signal peptide sequence followed by nine tandemly arranged epidermal growth factor (EGF)-like repeats, a spacer region, three cysteine-rich repeat motifs, and one CUB domain at the C terminus. However, little is known about its domain and biological function. Here, we generated a comprehensive panel of domain deletion constructs and a new genetic mouse model with targeted disruption of Scube1 (Scube1(Delta cub/Delta cub)) to investigate the domain function and biological significance. A number of cell-based assays were utilized to define the critical role of the spacer region for membrane association and establish that the EGF-like repeats 7-9 are sufficient for the formation of SCUBE1-mediated homophilic adhesions in a calcium-dependent fashion. Biochemical and molecular analyses showed that the C-terminal cysteine-rich motifs and CUB domain could directly bind and antagonize the bone morphogenetic protein activity. Furthermore, genetic ablation of this C-terminal region resulted in brain malformation in the Scube1(Delta cub/Delta cub) embryos. Together, our results support the dual roles of SCUBE1 on brain morphogenesis and cell-cell adhesions through its distinct domain function."xsd:string |
| http://purl.uniprot.org/citations/18303018 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m705872200"xsd:string |
| http://purl.uniprot.org/citations/18303018 | http://purl.uniprot.org/core/author | "Tu C.F."xsd:string |
| http://purl.uniprot.org/citations/18303018 | http://purl.uniprot.org/core/author | "Wu S.Y."xsd:string |
| http://purl.uniprot.org/citations/18303018 | http://purl.uniprot.org/core/author | "Yang R.B."xsd:string |
| http://purl.uniprot.org/citations/18303018 | http://purl.uniprot.org/core/author | "Yan Y.T."xsd:string |
| http://purl.uniprot.org/citations/18303018 | http://purl.uniprot.org/core/author | "Cheng C.J."xsd:string |
| http://purl.uniprot.org/citations/18303018 | http://purl.uniprot.org/core/author | "Tsai M.T."xsd:string |
| http://purl.uniprot.org/citations/18303018 | http://purl.uniprot.org/core/author | "Djoko B."xsd:string |
| http://purl.uniprot.org/citations/18303018 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18303018 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18303018 | http://purl.uniprot.org/core/pages | "12478-12488"xsd:string |
| http://purl.uniprot.org/citations/18303018 | http://purl.uniprot.org/core/title | "Domain and functional analysis of a novel platelet-endothelial cell surface protein, SCUBE1."xsd:string |
| http://purl.uniprot.org/citations/18303018 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18303018 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18303018 |
| http://purl.uniprot.org/citations/18303018 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18303018 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQV9-mappedCitation-18303018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18303018 |
| http://purl.uniprot.org/uniprot/#_A2A442-mappedCitation-18303018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18303018 |
| http://purl.uniprot.org/uniprot/#_E9PVX6-mappedCitation-18303018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18303018 |
| http://purl.uniprot.org/uniprot/#_Q68EF9-mappedCitation-18303018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18303018 |
| http://purl.uniprot.org/uniprot/#_Q6NZL8-mappedCitation-18303018 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18303018 |
| http://purl.uniprot.org/uniprot/Q6NZL8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18303018 |
| http://purl.uniprot.org/uniprot/Q68EF9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18303018 |
| http://purl.uniprot.org/uniprot/E9PVX6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18303018 |