| http://purl.uniprot.org/citations/18305108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18305108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18305108 | http://www.w3.org/2000/01/rdf-schema#comment | "We have recently identified Star-PAP, a nuclear poly(A) polymerase that associates with phosphatidylinositol-4-phosphate 5-kinase Ialpha (PIPKIalpha) and is required for the expression of a specific subset of mRNAs. Star-PAP activity is directly modulated by the PIPKIalpha product phosphatidylinositol 4,5-bisphosphate (PI-4,5-P(2)), linking nuclear phosphoinositide signaling to gene expression. Here, we show that PI-4,5-P(2)-dependent protein kinase activity is also a part of the Star-PAP protein complex. We identify the PI-4,5-P(2)-sensitive casein kinase Ialpha (CKIalpha) as a protein kinase responsible for this activity and further show that CKIalpha is capable of directly phosphorylating Star-PAP. Both CKIalpha and PIPKIalpha are required for the synthesis of some but not all Star-PAP target mRNA, and like Star-PAP, CKIalpha is associated with these messages in vivo. Taken together, these data indicate that CKIalpha, PIPKIalpha, and Star-PAP function together to modulate the production of specific Star-PAP messages. The Star-PAP complex therefore represents a location where multiple signaling pathways converge to regulate the expression of specific mRNAs."xsd:string |
| http://purl.uniprot.org/citations/18305108 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m800656200"xsd:string |
| http://purl.uniprot.org/citations/18305108 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m800656200"xsd:string |
| http://purl.uniprot.org/citations/18305108 | http://purl.uniprot.org/core/author | "Anderson R.A."xsd:string |
| http://purl.uniprot.org/citations/18305108 | http://purl.uniprot.org/core/author | "Anderson R.A."xsd:string |
| http://purl.uniprot.org/citations/18305108 | http://purl.uniprot.org/core/author | "Gonzales M.L."xsd:string |
| http://purl.uniprot.org/citations/18305108 | http://purl.uniprot.org/core/author | "Gonzales M.L."xsd:string |
| http://purl.uniprot.org/citations/18305108 | http://purl.uniprot.org/core/author | "Mellman D.L."xsd:string |
| http://purl.uniprot.org/citations/18305108 | http://purl.uniprot.org/core/author | "Mellman D.L."xsd:string |
| http://purl.uniprot.org/citations/18305108 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18305108 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18305108 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/18305108 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/18305108 | http://purl.uniprot.org/core/pages | "12665-12673"xsd:string |
| http://purl.uniprot.org/citations/18305108 | http://purl.uniprot.org/core/pages | "12665-12673"xsd:string |
| http://purl.uniprot.org/citations/18305108 | http://purl.uniprot.org/core/title | "CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs."xsd:string |
| http://purl.uniprot.org/citations/18305108 | http://purl.uniprot.org/core/title | "CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs."xsd:string |
| http://purl.uniprot.org/citations/18305108 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18305108 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18305108 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18305108 |
| http://purl.uniprot.org/citations/18305108 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18305108 |
| http://purl.uniprot.org/citations/18305108 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18305108 |
| http://purl.uniprot.org/citations/18305108 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18305108 |