| http://purl.uniprot.org/citations/18305173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18305173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18305173 | http://www.w3.org/2000/01/rdf-schema#comment | "In response to Toll-like receptor ligands, dendritic cells (DCs) dramatically enhance their antigen presentation capacity by stabilizing at the cell-surface MHC II molecules. We demonstrate here that, in human monocyte-derived DCs, the RING-CH ubiquitin E3 ligase, membrane-associated RING-CH I (MARCH I), promotes the ubiquitination of the HLA-DR beta-chain. Thus, in nonactivated DCs, MARCH I induces the surface internalization of mature HLA-DR complexes, therefore reducing their stability and levels. We further demonstrate that the maturation-dependent down-regulation of MARCH I is a key event in MHC class II up-regulation at the surface of LPS-activated DCs. MARCH I is, therefore, a major regulator of HLA-DR traffic, and its loss contributes to the acquisition of the potent immunostimulatory properties of mature human DCs."xsd:string |
| http://purl.uniprot.org/citations/18305173 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0708874105"xsd:string |
| http://purl.uniprot.org/citations/18305173 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0708874105"xsd:string |
| http://purl.uniprot.org/citations/18305173 | http://purl.uniprot.org/core/author | "Ceppi M."xsd:string |
| http://purl.uniprot.org/citations/18305173 | http://purl.uniprot.org/core/author | "Ceppi M."xsd:string |
| http://purl.uniprot.org/citations/18305173 | http://purl.uniprot.org/core/author | "Catalan N."xsd:string |
| http://purl.uniprot.org/citations/18305173 | http://purl.uniprot.org/core/author | "Catalan N."xsd:string |
| http://purl.uniprot.org/citations/18305173 | http://purl.uniprot.org/core/author | "De Gassart A."xsd:string |
| http://purl.uniprot.org/citations/18305173 | http://purl.uniprot.org/core/author | "De Gassart A."xsd:string |
| http://purl.uniprot.org/citations/18305173 | http://purl.uniprot.org/core/author | "Pierre P."xsd:string |
| http://purl.uniprot.org/citations/18305173 | http://purl.uniprot.org/core/author | "Pierre P."xsd:string |
| http://purl.uniprot.org/citations/18305173 | http://purl.uniprot.org/core/author | "Gatti E."xsd:string |
| http://purl.uniprot.org/citations/18305173 | http://purl.uniprot.org/core/author | "Gatti E."xsd:string |
| http://purl.uniprot.org/citations/18305173 | http://purl.uniprot.org/core/author | "Camosseto V."xsd:string |
| http://purl.uniprot.org/citations/18305173 | http://purl.uniprot.org/core/author | "Camosseto V."xsd:string |
| http://purl.uniprot.org/citations/18305173 | http://purl.uniprot.org/core/author | "Thibodeau J."xsd:string |
| http://purl.uniprot.org/citations/18305173 | http://purl.uniprot.org/core/author | "Thibodeau J."xsd:string |
| http://purl.uniprot.org/citations/18305173 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18305173 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18305173 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/18305173 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/18305173 | http://purl.uniprot.org/core/pages | "3491-3496"xsd:string |
| http://purl.uniprot.org/citations/18305173 | http://purl.uniprot.org/core/pages | "3491-3496"xsd:string |