| http://purl.uniprot.org/citations/18307834 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18307834 | http://www.w3.org/2000/01/rdf-schema#comment | "The oligomeric structure and the residual propeptide are distinct characteristics of cathepsin C from other members in the papain superfamily. In this study, we examined the physiological role of the cathepsin C propeptide. The stable overexpression of cathepsin C propeptide significantly decreased the activities of intestinal alkaline phosphatase (IAP) and sucrase in human Caco-2 intestinal epithelial cells, whereas it did not change the proliferation and cathepsin C activity. The overexpression of cathepsin C propeptide significantly decreased the amounts of IAP protein in differentiated Caco-2 cells, compared with the transfection of mock vector, whereas the amounts of IAP transcripts were not changed. Pulse-chase analysis confirmed that the reduction in IAP activity was due to an increase in IAP degradation, but not a decrease in IAP expression. For the mechanism of the enhanced IAP degradation, we identified proteins interacting with cathepsin C propeptide in Caco-2 cells by immunoprecipitation and mass spectrometry. Cathepsin C propeptide interacted with proteins with a molecular mass of approximately 70 kDa, including IAP and heat shock cognate protein 70. Our present results suggest that the propeptide of cathepsin C may stimulate the sorting to the lysosome, at least in part, contributing to the degradation of IAP in Caco-2 cells."xsd:string |
| http://purl.uniprot.org/citations/18307834 | http://purl.org/dc/terms/identifier | "doi:10.2170/physiolsci.rp013007"xsd:string |
| http://purl.uniprot.org/citations/18307834 | http://purl.uniprot.org/core/author | "Yamada C."xsd:string |
| http://purl.uniprot.org/citations/18307834 | http://purl.uniprot.org/core/author | "Tokuoka K."xsd:string |
| http://purl.uniprot.org/citations/18307834 | http://purl.uniprot.org/core/author | "Nakao R."xsd:string |
| http://purl.uniprot.org/citations/18307834 | http://purl.uniprot.org/core/author | "Okumura Y."xsd:string |
| http://purl.uniprot.org/citations/18307834 | http://purl.uniprot.org/core/author | "Imagawa T."xsd:string |
| http://purl.uniprot.org/citations/18307834 | http://purl.uniprot.org/core/author | "Kishi K."xsd:string |
| http://purl.uniprot.org/citations/18307834 | http://purl.uniprot.org/core/author | "Ishidoh K."xsd:string |
| http://purl.uniprot.org/citations/18307834 | http://purl.uniprot.org/core/author | "Nikawa T."xsd:string |
| http://purl.uniprot.org/citations/18307834 | http://purl.uniprot.org/core/author | "Hirasaka K."xsd:string |
| http://purl.uniprot.org/citations/18307834 | http://purl.uniprot.org/core/author | "Oarada M."xsd:string |
| http://purl.uniprot.org/citations/18307834 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18307834 | http://purl.uniprot.org/core/name | "J Physiol Sci"xsd:string |
| http://purl.uniprot.org/citations/18307834 | http://purl.uniprot.org/core/pages | "105-111"xsd:string |
| http://purl.uniprot.org/citations/18307834 | http://purl.uniprot.org/core/title | "Cathepsin C propeptide interacts with intestinal alkaline phosphatase and heat shock cognate protein 70 in human Caco-2 cells."xsd:string |
| http://purl.uniprot.org/citations/18307834 | http://purl.uniprot.org/core/volume | "58"xsd:string |
| http://purl.uniprot.org/citations/18307834 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18307834 |
| http://purl.uniprot.org/citations/18307834 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18307834 |
| http://purl.uniprot.org/uniprot/P80067#attribution-68D911C2958F0A677969556D8150E7D5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18307834 |
| http://purl.uniprot.org/uniprot/P80067#attribution-E5124417695F019465EBD2C3AB857A18 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18307834 |
| http://purl.uniprot.org/uniprot/P53634#attribution-3A473686F63A67803D1092D44CB8329C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18307834 |
| http://purl.uniprot.org/uniprot/P09923#attribution-68D911C2958F0A677969556D8150E7D5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18307834 |
| http://purl.uniprot.org/uniprot/#_D4A4S3-mappedCitation-18307834 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18307834 |