| http://purl.uniprot.org/citations/18308937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18308937 | http://www.w3.org/2000/01/rdf-schema#comment | "Understanding transdifferentiation-the conversion of one differentiated cell type into another-is important from both basic science and clinical perspectives. In Caenorhabditis elegans, an epithelial cell named Y is initially part of the rectum but later appears to withdraw, migrate, and then become a motor neuron named PDA. Here, we show that this represents a bona fide transdifferentiation event: Y has epithelial hallmarks without detectable neural characteristics, and PDA has no residual epithelial characteristics. Using available mutants and laser microsurgery, we found that transdifferentiation does not depend on fusion with a neighboring cell or require migration of Y away from the rectum, that other rectal epithelial cells are not competent to transdifferentiate, and that transdifferentiation requires the EGL-5 and SEM-4 transcription factors and LIN-12/Notch signaling. Our results establish Y-to-PDA transdifferentiation as a genetically tractable model for deciphering the mechanisms underlying cellular plasticity in vivo."xsd:string |
| http://purl.uniprot.org/citations/18308937 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0712159105"xsd:string |
| http://purl.uniprot.org/citations/18308937 | http://purl.uniprot.org/core/author | "Greenwald I."xsd:string |
| http://purl.uniprot.org/citations/18308937 | http://purl.uniprot.org/core/author | "Jarriault S."xsd:string |
| http://purl.uniprot.org/citations/18308937 | http://purl.uniprot.org/core/author | "Schwab Y."xsd:string |
| http://purl.uniprot.org/citations/18308937 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18308937 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/18308937 | http://purl.uniprot.org/core/pages | "3790-3795"xsd:string |
| http://purl.uniprot.org/citations/18308937 | http://purl.uniprot.org/core/title | "A Caenorhabditis elegans model for epithelial-neuronal transdifferentiation."xsd:string |
| http://purl.uniprot.org/citations/18308937 | http://purl.uniprot.org/core/volume | "105"xsd:string |
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