| http://purl.uniprot.org/citations/18311922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18311922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18311922 | http://www.w3.org/2000/01/rdf-schema#comment | "A novel class of lipids, N-acyltaurines, was recently discovered in fatty acid amide hydrolase knockout mice. In some peripheral tissues, such as liver and kidney, N-acyltaurines with long, polyunsaturated acyl chains are most prevalent. Polyunsaturated fatty acids are converted to a variety of signaling molecules by cyclooxygenases (COXs) and lipoxygenases (LOXs). The ability of COXs and LOXs to oxygenate arachidonoyltaurine was evaluated to gain insight into the potential metabolic fate of N-acyltaurines. Although arachidonoyltaurine was a poor substrate for COXs, mammalian 12 S- and 15 S-LOXs oxygenated arachidonoyltaurine with similar or better efficiency than arachidonic acid. Products of arachidonoyltaurine oxygenation were characterized by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The positional specificity of single oxygenation was retained for 15 S-LOXs. However, platelet-type 12 S-LOX produced 12- and 15-hydroxyeicosatetraenoyltaurines (HETE-Ts). Furthermore, LOXs generated dihydroxyeicosatetraenoyltaurines (diHETE-Ts). Metabolism of arachidonoyltaurine by murine resident peritoneal macrophages (RPMs) was also profiled. Arachidonoyltaurine was rapidly taken up and converted primarily to 12-HETE-T. Over prolonged incubations, RPMs also generated small amounts of diHETE-T. Oxidative metabolism of polyunsaturated N-acyltaurines may represent a pathway for the generation or termination of novel signaling molecules."xsd:string |
| http://purl.uniprot.org/citations/18311922 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi702530z"xsd:string |
| http://purl.uniprot.org/citations/18311922 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi702530z"xsd:string |
| http://purl.uniprot.org/citations/18311922 | http://purl.uniprot.org/core/author | "Cravatt B.F."xsd:string |
| http://purl.uniprot.org/citations/18311922 | http://purl.uniprot.org/core/author | "Cravatt B.F."xsd:string |
| http://purl.uniprot.org/citations/18311922 | http://purl.uniprot.org/core/author | "Kingsley P.J."xsd:string |
| http://purl.uniprot.org/citations/18311922 | http://purl.uniprot.org/core/author | "Kingsley P.J."xsd:string |
| http://purl.uniprot.org/citations/18311922 | http://purl.uniprot.org/core/author | "Marnett L.J."xsd:string |
| http://purl.uniprot.org/citations/18311922 | http://purl.uniprot.org/core/author | "Marnett L.J."xsd:string |
| http://purl.uniprot.org/citations/18311922 | http://purl.uniprot.org/core/author | "Rouzer C.A."xsd:string |
| http://purl.uniprot.org/citations/18311922 | http://purl.uniprot.org/core/author | "Rouzer C.A."xsd:string |
| http://purl.uniprot.org/citations/18311922 | http://purl.uniprot.org/core/author | "Turman M.V."xsd:string |
| http://purl.uniprot.org/citations/18311922 | http://purl.uniprot.org/core/author | "Turman M.V."xsd:string |
| http://purl.uniprot.org/citations/18311922 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18311922 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18311922 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/18311922 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/18311922 | http://purl.uniprot.org/core/pages | "3917-3925"xsd:string |
| http://purl.uniprot.org/citations/18311922 | http://purl.uniprot.org/core/pages | "3917-3925"xsd:string |
| http://purl.uniprot.org/citations/18311922 | http://purl.uniprot.org/core/title | "Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine."xsd:string |
| http://purl.uniprot.org/citations/18311922 | http://purl.uniprot.org/core/title | "Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine."xsd:string |
| http://purl.uniprot.org/citations/18311922 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/18311922 | http://purl.uniprot.org/core/volume | "47"xsd:string |