| http://purl.uniprot.org/citations/18313668 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18313668 | http://www.w3.org/2000/01/rdf-schema#comment | "The Ikaros (Ik) family of transcription factors has critical functions in immune regulation, lymphohematopoiesis and the hypothalamic-pituitary axis. Ik influences cell fate decisions through transcriptional activation of target genes and its interaction with chromatin remodeling complexes. While Ik is well-described in the lymphoid system and pituitary, its presence and function in the brain has received limited attention to date. This study describes the transient spatio-temporal expression of Ik in striatal medium spiny neurons of the developing murine CNS. To determine the impact of Ik deficiency, standardized behavioral tests were performed. In the elevated plus-maze and contextual fear conditioning tests, homozygous Ik-deficient mice performed similarly to wild-type or heterozygote mice. However, significant differences were observed in Ik-null mice in several behavioral tests. Pinch-induced catalepsy was markedly extended. In the Porsolt forced swim test, Ik-null mice showed reduced immobility, consistent with an anti-depressive effect. The acoustic startle response of Ik-null mice was also markedly diminished. Our findings extend the role of the Ikaros zinc-finger protein to the maturation and differentiation of striatal medium spiny neurons and indicate important actions for Ik in the development of neurocognitive functions and affecting depressive behaviors."xsd:string |
| http://purl.uniprot.org/citations/18313668 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.expneurol.2008.01.014"xsd:string |
| http://purl.uniprot.org/citations/18313668 | http://purl.uniprot.org/core/author | "Fischer S.E."xsd:string |
| http://purl.uniprot.org/citations/18313668 | http://purl.uniprot.org/core/author | "Kiehl T.R."xsd:string |
| http://purl.uniprot.org/citations/18313668 | http://purl.uniprot.org/core/author | "Asa S.L."xsd:string |
| http://purl.uniprot.org/citations/18313668 | http://purl.uniprot.org/core/author | "Ezzat S."xsd:string |
| http://purl.uniprot.org/citations/18313668 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18313668 | http://purl.uniprot.org/core/name | "Exp Neurol"xsd:string |
| http://purl.uniprot.org/citations/18313668 | http://purl.uniprot.org/core/pages | "107-114"xsd:string |
| http://purl.uniprot.org/citations/18313668 | http://purl.uniprot.org/core/title | "Mice lacking the transcription factor Ikaros display behavioral alterations of an anti-depressive phenotype."xsd:string |
| http://purl.uniprot.org/citations/18313668 | http://purl.uniprot.org/core/volume | "211"xsd:string |
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