| http://purl.uniprot.org/citations/18316378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18316378 | http://www.w3.org/2000/01/rdf-schema#comment | "The salient feature of dendritic cells (DC) is the initiation of appropriate adaptive immune responses by discriminating between pathogens. Using a prototypic model of intracellular infection, we previously showed that Leishmania major parasites prime human DC for efficient interleukin-12 (IL-12) secretion. L. major infection is associated with self-limiting cutaneous disease and powerful immunity. In stark contrast, the causative agent of visceral leishmaniasis, Leishmania donovani, does not prime human DC for IL-12 production. Here, we report that DC priming by L. major infection results in the early activation of NF-kappaB transcription factors and the up-regulation and nuclear translocation of interferon regulatory factor 1 (IRF-1) and IRF-8. The inhibition of NF-kappaB activation by the pretreatment of DC with caffeic acid phenethyl ester blocks L. major-induced IRF-1 and IRF-8 activation and IL-12 expression. We further demonstrate that IRF-1 and IRF-8 obtained from L. major-infected human DC specifically bind to their consensus binding sites on the IL-12p35 promoter, indicating that L. major infection either directly stimulates a signaling cascade or induces an autocrine pathway that activates IRF-1 and IRF-8, ultimately resulting in IL-12 transcription."xsd:string |
| http://purl.uniprot.org/citations/18316378 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.01252-07"xsd:string |
| http://purl.uniprot.org/citations/18316378 | http://purl.uniprot.org/core/author | "Jayakumar A."xsd:string |
| http://purl.uniprot.org/citations/18316378 | http://purl.uniprot.org/core/author | "Tripathi V."xsd:string |
| http://purl.uniprot.org/citations/18316378 | http://purl.uniprot.org/core/author | "McDowell M.A."xsd:string |
| http://purl.uniprot.org/citations/18316378 | http://purl.uniprot.org/core/author | "Donovan M.J."xsd:string |
| http://purl.uniprot.org/citations/18316378 | http://purl.uniprot.org/core/author | "Ramalho-Ortigao M."xsd:string |
| http://purl.uniprot.org/citations/18316378 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18316378 | http://purl.uniprot.org/core/name | "Infect Immun"xsd:string |
| http://purl.uniprot.org/citations/18316378 | http://purl.uniprot.org/core/pages | "2138-2148"xsd:string |
| http://purl.uniprot.org/citations/18316378 | http://purl.uniprot.org/core/title | "Leishmania major infection activates NF-kappaB and interferon regulatory factors 1 and 8 in human dendritic cells."xsd:string |
| http://purl.uniprot.org/citations/18316378 | http://purl.uniprot.org/core/volume | "76"xsd:string |
| http://purl.uniprot.org/citations/18316378 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18316378 |
| http://purl.uniprot.org/citations/18316378 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18316378 |
| http://purl.uniprot.org/uniprot/#_A0A0B6XK53-mappedCitation-18316378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18316378 |
| http://purl.uniprot.org/uniprot/#_A0A0B6XK11-mappedCitation-18316378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18316378 |
| http://purl.uniprot.org/uniprot/#_A0A1B1RS94-mappedCitation-18316378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18316378 |
| http://purl.uniprot.org/uniprot/#_A0A510GAH8-mappedCitation-18316378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18316378 |
| http://purl.uniprot.org/uniprot/#_A0A510GDD8-mappedCitation-18316378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18316378 |
| http://purl.uniprot.org/uniprot/#_B2R8V7-mappedCitation-18316378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18316378 |
| http://purl.uniprot.org/uniprot/#_B4DQF0-mappedCitation-18316378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18316378 |
| http://purl.uniprot.org/uniprot/#_P10914-mappedCitation-18316378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18316378 |
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| http://purl.uniprot.org/uniprot/#_Q75MZ8-mappedCitation-18316378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18316378 |