| http://purl.uniprot.org/citations/18316611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18316611 | http://www.w3.org/2000/01/rdf-schema#comment | "Her2 is overexpressed in 20% to 30% of breast tumors and correlates with reduced disease-free and overall patient survival. Trastuzumab, a humanized monoclonal antibody directed against Her2, represents the first Her2-targeted therapy, which decreases the risk of relapse and prolongs patient survival. Resistance to trastuzumab, both inherent and treatment-acquired, represents a significant barrier to the effective treatment of Her2 (+) breast cancer. The Met receptor tyrosine kinase is aberrantly expressed in breast cancer and predicts poor patient prognosis. In this study, we find that Met is frequently expressed in Her2-overexpressing breast cancer cells, as well as Her2 (+) breast cancer. Importantly, Met contributes to trastuzumab resistance, as inhibition of Met sensitizes cells to trastuzumab-mediated growth inhibition, whereas Met activation protects cells against trastuzumab by abrogating p27 induction. Remarkably, Her2-overexpressing breast cancer cells rapidly up-regulate Met expression after trastuzumab treatment, promoting their own resistance. Our study suggests that a subset of Her2 (+) patients may benefit from combined inhibition of Her2 and Met."xsd:string |
| http://purl.uniprot.org/citations/18316611 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-07-5962"xsd:string |
| http://purl.uniprot.org/citations/18316611 | http://purl.uniprot.org/core/author | "Miller J.K."xsd:string |
| http://purl.uniprot.org/citations/18316611 | http://purl.uniprot.org/core/author | "Sweeney C."xsd:string |
| http://purl.uniprot.org/citations/18316611 | http://purl.uniprot.org/core/author | "Carraway K.L."xsd:string |
| http://purl.uniprot.org/citations/18316611 | http://purl.uniprot.org/core/author | "Shattuck D.L."xsd:string |
| http://purl.uniprot.org/citations/18316611 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18316611 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/18316611 | http://purl.uniprot.org/core/pages | "1471-1477"xsd:string |
| http://purl.uniprot.org/citations/18316611 | http://purl.uniprot.org/core/title | "Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/18316611 | http://purl.uniprot.org/core/volume | "68"xsd:string |
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