| http://purl.uniprot.org/citations/18317410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18317410 | http://www.w3.org/2000/01/rdf-schema#comment | "Ischemic heart disease is a common age-related disease. Apoptotic cell death and inflammation are the major contributors to I/R injury. The mechanisms that trigger myocyte apoptosis and inflammation during myocardial I/R (MI/R) remain to be elucidated. Published data from our laboratory demonstrated that pretreatment of MI/R rats with pifithrin-alpha (PFT), a specific p53 inhibitor, reduced myocyte apoptosis and improved cardiac function compared with MI/R rats pretreated with saline at 4 h of reperfusion. In the present study, we investigated the effects of PFT on the occurrence of myocyte apoptosis and leukocyte transmigration in the later period of reperfusion. Aged (20-month-old) male F344 rats were subjected to 30 min of myocardial ischemia via ligature of the LCA, followed by 24 h of reperfusion. Pifithrin-alpha (2.2 mg/kg, intraperitoneally) or saline was administered to rats before ischemia. The results indicate that pretreatment of MI/R rats with PFT significantly decreased the percentage of infarct area to ischemic area (33 +/- 8 vs. 54 +/-9, P < 0.05) and improved cardiac output (79 +/- 11 vs. 38 +/-9 mL/min per 100 g body weight, P < 0.05) when compared with rats pretreated with saline at 24 h of reperfusion. The protective effects of PFT may involve the p53/Bax-mediated apoptosis because treatment of MI/R rats with PFT attenuated the ratio of Bax to Bcl2 (0.97 +/- 0.1 vs. 2.1 +/-0.2, P < 0.05) and reduced myocyte apoptosis. Interestingly, inhibition of p53 transcriptional function by PFT alleviated leukocyte infiltration into the ischemic area of the heart (339 +/- 37 vs. 498 +/-75 cells/10 high-power fields, P < 0.05). These data suggest that inhibition of p53 transcriptional function by PFT attenuates myocyte apoptosis and alleviates leukocyte transmigration at 24 h of reperfusion. The mechanisms by which p53 modulates leukocyte transmigration require further investigation."xsd:string |
| http://purl.uniprot.org/citations/18317410 | http://purl.org/dc/terms/identifier | "doi:10.1097/shk.0b013e31816a192d"xsd:string |
| http://purl.uniprot.org/citations/18317410 | http://purl.uniprot.org/core/author | "Liu P."xsd:string |
| http://purl.uniprot.org/citations/18317410 | http://purl.uniprot.org/core/author | "Xu B."xsd:string |
| http://purl.uniprot.org/citations/18317410 | http://purl.uniprot.org/core/author | "Cavalieri T.A."xsd:string |
| http://purl.uniprot.org/citations/18317410 | http://purl.uniprot.org/core/author | "Hock C.E."xsd:string |
| http://purl.uniprot.org/citations/18317410 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18317410 | http://purl.uniprot.org/core/name | "Shock"xsd:string |
| http://purl.uniprot.org/citations/18317410 | http://purl.uniprot.org/core/pages | "545-551"xsd:string |
| http://purl.uniprot.org/citations/18317410 | http://purl.uniprot.org/core/title | "Inhibition of p53 by pifithrin-alpha reduces myocyte apoptosis and leukocyte transmigration in aged rat hearts following 24 hours of reperfusion."xsd:string |
| http://purl.uniprot.org/citations/18317410 | http://purl.uniprot.org/core/volume | "30"xsd:string |
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