| http://purl.uniprot.org/citations/18318613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18318613 | http://www.w3.org/2000/01/rdf-schema#comment | "The GTPase activating protein, RGS9-1, is vital for the deactivation and regulation of the phototransduction cascade (C. K. Chen et al., 2000; C. W. Cowan, R. N. Fariss, I. Sokal, K. Palczewski, & T. G. Wensel, 1998; W. He, C. W. Cowan, & T. G. Wensel, 1998; A. L. Lyubarsky et al., 2001). Its loss through genetic defects in humans has been linked to a slow recovery to changes in illumination (K. M. Nishiguchi et al., 2004). Such a deficit is to be expected because RGS9-1 normally speeds up the deactivation of the activated phosphodiesterase effector molecule, PDE6*, and thus accelerates the turning off of the visual response. Paradoxically, however, we find that the cone response in an observer lacking RGS9-1 is faster at lower light levels than it is in a normal observer. Though surprising, this result is nonetheless consistent with molecular models of light adaptation (e.g., E. N. Pugh, S. Nikonov, & T. D. Lamb, 1999), which predict that the excess of PDE6* resulting from the loss of RGS9-1 will shorten the visual integration time and speed up the visual response at inappropriately low light levels. The gain in speed caused by the superfluity of PDE6* at lower light levels compensates for the loss caused by its slow deactivation; thus quickening the response relative to that in the normal. As the light level is increased and the PDE6* concentration in the normal rises relative to that in the observer lacking RGS9-1, the temporal advantage of the latter is soon lost, leaving only the deficit due to delayed deactivation."xsd:string |
| http://purl.uniprot.org/citations/18318613 | http://purl.org/dc/terms/identifier | "doi:10.1167/8.1.10"xsd:string |
| http://purl.uniprot.org/citations/18318613 | http://purl.uniprot.org/core/author | "Webster A.R."xsd:string |
| http://purl.uniprot.org/citations/18318613 | http://purl.uniprot.org/core/author | "Holder G.E."xsd:string |
| http://purl.uniprot.org/citations/18318613 | http://purl.uniprot.org/core/author | "Sharpe L.T."xsd:string |
| http://purl.uniprot.org/citations/18318613 | http://purl.uniprot.org/core/author | "Rana N.A."xsd:string |
| http://purl.uniprot.org/citations/18318613 | http://purl.uniprot.org/core/author | "Stockman A."xsd:string |
| http://purl.uniprot.org/citations/18318613 | http://purl.uniprot.org/core/author | "Ripamonti C."xsd:string |
| http://purl.uniprot.org/citations/18318613 | http://purl.uniprot.org/core/author | "Smithson H.E."xsd:string |
| http://purl.uniprot.org/citations/18318613 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18318613 | http://purl.uniprot.org/core/name | "J Vis"xsd:string |
| http://purl.uniprot.org/citations/18318613 | http://purl.uniprot.org/core/pages | "10.1-10"xsd:string |
| http://purl.uniprot.org/citations/18318613 | http://purl.uniprot.org/core/title | "The loss of the PDE6 deactivating enzyme, RGS9, results in precocious light adaptation at low light levels."xsd:string |
| http://purl.uniprot.org/citations/18318613 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/18318613 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18318613 |
| http://purl.uniprot.org/citations/18318613 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18318613 |
| http://purl.uniprot.org/uniprot/#_Q6ZS82-mappedCitation-18318613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18318613 |
| http://purl.uniprot.org/uniprot/Q6ZS82 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18318613 |