| http://purl.uniprot.org/citations/18319254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18319254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18319254 | http://www.w3.org/2000/01/rdf-schema#comment | "The SLC4A10 gene product, commonly known as NCBE, is highly expressed in rodent brain and has been characterized by others as a Na(+)-driven Cl-HCO(3) exchanger. However, some of the earlier data are not consistent with Na(+)-driven Cl-HCO(3) exchange activity. In the present study, northern blot analysis showed that, also in humans, NCBE transcripts are predominantly expressed in brain. In some human NCBE transcripts, splice cassettes A and/or B, originally reported in rats and mice, are spliced out. In brain cDNA, we found evidence of a unique partial splice of cassette B that is predicted to produce an NCBE protein with a novel C terminus containing a protein kinase C phosphorylation site. We used pH-sensitive microelectrodes to study the molecular physiology of human NCBE expressed in Xenopus oocytes. In agreement with others we found that NCBE mediates the 4,4'-diisothiocyanato-stilbene-2,2'-disulfonic acid-sensitive, Na(+)-dependent transport of HCO(3)(-). For the first time, we demonstrated that this transport process is electroneutral. Using Cl(-)-sensitive microelectrodes positioned at the oocyte surface, we found that, unlike both human and squid Na(+)-driven Cl-HCO(3) exchangers, human NCBE does not normally couple the net influx of HCO(3)(-) to a net efflux of Cl(-). Moreover we found that that the (36)Cl efflux from NCBE-expressing oocytes, interpreted by others to be coupled to the influx of Na(+) and HCO(3)(-), actually represents a CO(2)/HCO(3)(-)-stimulated Cl(-) self-exchange not coupled to either Na(+) or net HCO(3)(-) transport. We propose to rename NCBE as the second electroneutral Na/HCO(3) cotransporter, NBCn2."xsd:string |
| http://purl.uniprot.org/citations/18319254 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m707829200"xsd:string |
| http://purl.uniprot.org/citations/18319254 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m707829200"xsd:string |
| http://purl.uniprot.org/citations/18319254 | http://purl.uniprot.org/core/author | "Parker M.D."xsd:string |
| http://purl.uniprot.org/citations/18319254 | http://purl.uniprot.org/core/author | "Parker M.D."xsd:string |
| http://purl.uniprot.org/citations/18319254 | http://purl.uniprot.org/core/author | "Choi I."xsd:string |
| http://purl.uniprot.org/citations/18319254 | http://purl.uniprot.org/core/author | "Choi I."xsd:string |
| http://purl.uniprot.org/citations/18319254 | http://purl.uniprot.org/core/author | "Boron W.F."xsd:string |
| http://purl.uniprot.org/citations/18319254 | http://purl.uniprot.org/core/author | "Boron W.F."xsd:string |
| http://purl.uniprot.org/citations/18319254 | http://purl.uniprot.org/core/author | "Musa-Aziz R."xsd:string |
| http://purl.uniprot.org/citations/18319254 | http://purl.uniprot.org/core/author | "Musa-Aziz R."xsd:string |
| http://purl.uniprot.org/citations/18319254 | http://purl.uniprot.org/core/author | "Daly C.M."xsd:string |
| http://purl.uniprot.org/citations/18319254 | http://purl.uniprot.org/core/author | "Daly C.M."xsd:string |
| http://purl.uniprot.org/citations/18319254 | http://purl.uniprot.org/core/author | "Rojas J.D."xsd:string |
| http://purl.uniprot.org/citations/18319254 | http://purl.uniprot.org/core/author | "Rojas J.D."xsd:string |
| http://purl.uniprot.org/citations/18319254 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18319254 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18319254 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/18319254 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/18319254 | http://purl.uniprot.org/core/pages | "12777-12788"xsd:string |
| http://purl.uniprot.org/citations/18319254 | http://purl.uniprot.org/core/pages | "12777-12788"xsd:string |
| http://purl.uniprot.org/citations/18319254 | http://purl.uniprot.org/core/title | "Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl- self-exchange activity."xsd:string |
| http://purl.uniprot.org/citations/18319254 | http://purl.uniprot.org/core/title | "Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl- self-exchange activity."xsd:string |