| http://purl.uniprot.org/citations/18322222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18322222 | http://www.w3.org/2000/01/rdf-schema#comment | "Type I IFN (IFN-I) signaling is detrimental to cells and mice infected with Listeria monocytogenes. In this study, we investigate the impact of IFN-I on the activity of listeriolysin O (LLO), a pore-forming toxin and virulence protein released by L. monocytogenes. Treatment of macrophages with IFN-beta increased the ability of sublytic LLO concentrations to cause transient permeability of the plasma membrane. At higher LLO concentrations, IFN-beta enhanced the complete breakdown of membrane integrity and cell death. This activity of IFN-beta required Stat1. Perturbation of the plasma membrane by LLO resulted in activation of the p38MAPK pathway. IFN-beta pretreatment enhanced LLO-mediated signaling through this pathway, consistent with its ability to increase membrane damage. p38MAPK activation in response to LLO was independent of TLR4, a putative LLO receptor, and inhibition of p38MAPK neither enhanced nor prevented LLO-induced death. IFN-beta caused cells to express increased amounts of caspase 1 and to produce a detectable caspase 1 cleavage product after LLO treatment. Contrasting recent reports with another pore-forming toxin, this pathway did not aid cell survival as caspase 1-deficient cells were equally sensitive to lysis by LLO. Key lipogenesis enzymes were suppressed in IFN-beta-treated cells, which may exacerbate the membrane damage caused by LLO."xsd:string |
| http://purl.uniprot.org/citations/18322222 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.180.6.4116"xsd:string |
| http://purl.uniprot.org/citations/18322222 | http://purl.uniprot.org/core/author | "Decker T."xsd:string |
| http://purl.uniprot.org/citations/18322222 | http://purl.uniprot.org/core/author | "Lemmens-Gruber R."xsd:string |
| http://purl.uniprot.org/citations/18322222 | http://purl.uniprot.org/core/author | "Stockinger S."xsd:string |
| http://purl.uniprot.org/citations/18322222 | http://purl.uniprot.org/core/author | "Zwaferink H."xsd:string |
| http://purl.uniprot.org/citations/18322222 | http://purl.uniprot.org/core/author | "Hazemi P."xsd:string |
| http://purl.uniprot.org/citations/18322222 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18322222 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18322222 | http://purl.uniprot.org/core/pages | "4116-4123"xsd:string |
| http://purl.uniprot.org/citations/18322222 | http://purl.uniprot.org/core/title | "IFN-beta increases listeriolysin O-induced membrane permeabilization and death of macrophages."xsd:string |
| http://purl.uniprot.org/citations/18322222 | http://purl.uniprot.org/core/volume | "180"xsd:string |
| http://purl.uniprot.org/citations/18322222 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18322222 |
| http://purl.uniprot.org/citations/18322222 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18322222 |
| http://purl.uniprot.org/uniprot/#_A0A087WSP5-mappedCitation-18322222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18322222 |
| http://purl.uniprot.org/uniprot/#_A0A087WSQ5-mappedCitation-18322222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18322222 |
| http://purl.uniprot.org/uniprot/#_A0A087WRI1-mappedCitation-18322222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18322222 |
| http://purl.uniprot.org/uniprot/#_Q0PM15-mappedCitation-18322222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18322222 |
| http://purl.uniprot.org/uniprot/#_Q0PM16-mappedCitation-18322222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18322222 |
| http://purl.uniprot.org/uniprot/#_Q0VE17-mappedCitation-18322222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18322222 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLE4-mappedCitation-18322222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18322222 |
| http://purl.uniprot.org/uniprot/#_A0A571BDI1-mappedCitation-18322222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18322222 |
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| http://purl.uniprot.org/uniprot/#_A0A3B2WB60-mappedCitation-18322222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18322222 |