| http://purl.uniprot.org/citations/18322246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18322246 | http://www.w3.org/2000/01/rdf-schema#comment | "Asthma is an allergic disease characterized by chronic airway eosinophilia and pulmonary infiltration of lymphocytes, particularly of the Th2 subtype, macrophages and mast cells. Previous studies have shown a pivotal role for sphingosine kinase (SphK) on various proinflammatory cells, such as lymphocyte and eosinophil migration and mast cell degranulation. We therefore examined the roles of SphK in a murine model of allergic asthma. In mice previously sensitized to OVA, i.p. administration of N,N-dimethylsphingosine (DMS), a potent SphK inhibitor, significantly reduced the total inflammatory cell infiltrate and eosinophilia and the IL-4, IL-5, and eotaxin levels in bronchoalveolar lavage fluid in response to inhaled OVA challenge. In addition, DMS significantly suppressed OVA-induced inflammatory infiltrates and mucus production in the lungs, and airway hyperresponsiveness to methacholine in a dose-dependent manner. OVA-induced lymphocyte proliferation and IL-4 and IL-5 secretion were reduced in thoracic lymph node cultures from DMS-treated mice. Moreover, similar reduction in inflammatory infiltrates, bronchoalveolar lavage, IL-4, IL-5, eotaxin, and serum OVA-specific IgE levels was observed in mice with SphK1 knock-down via small interfering RNA approach. Together, these data demonstrate the therapeutic potential of SphK modulation in allergic airways disease."xsd:string |
| http://purl.uniprot.org/citations/18322246 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.180.6.4323"xsd:string |
| http://purl.uniprot.org/citations/18322246 | http://purl.uniprot.org/core/author | "Bao Z."xsd:string |
| http://purl.uniprot.org/citations/18322246 | http://purl.uniprot.org/core/author | "Wong W.S."xsd:string |
| http://purl.uniprot.org/citations/18322246 | http://purl.uniprot.org/core/author | "Leung B.P."xsd:string |
| http://purl.uniprot.org/citations/18322246 | http://purl.uniprot.org/core/author | "Melendez A.J."xsd:string |
| http://purl.uniprot.org/citations/18322246 | http://purl.uniprot.org/core/author | "Goh H.H."xsd:string |
| http://purl.uniprot.org/citations/18322246 | http://purl.uniprot.org/core/author | "Lai W.Q."xsd:string |
| http://purl.uniprot.org/citations/18322246 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18322246 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18322246 | http://purl.uniprot.org/core/pages | "4323-4329"xsd:string |
| http://purl.uniprot.org/citations/18322246 | http://purl.uniprot.org/core/title | "The role of sphingosine kinase in a murine model of allergic asthma."xsd:string |
| http://purl.uniprot.org/citations/18322246 | http://purl.uniprot.org/core/volume | "180"xsd:string |
| http://purl.uniprot.org/citations/18322246 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18322246 |
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