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http://purl.uniprot.org/citations/18322954http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18322954http://www.w3.org/2000/01/rdf-schema#comment"

Aim

To investigate the relationship between loss of heterozygosity (LOH) for mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) and the outcomes for primary HCC patients treated with partial hepatectomy.

Methods

The LOH for M6P/IGF2R in primary HCC patients was assessed using six different gene-specific nucleotide polymorphisms. The patients studied were enrolled to undergo partial hepatectomy.

Results

M6P/IGF2R was found to be polymorphic in 73.3% (22/30) of the patients, and of these patients, 50.0% (11/22) had tumors showing LOH in M6P/IGF2R. Loss of heterozygosity in M6P/IGF2R was associated with significant reductions in the two year overall survival rate (24.9% vs 65.5%; P=0.04) and the disease-free survival rate (17.8% vs 59.3%; P=0.03).

Conclusion

These results show M6P/IGF2R LOH predicts poor clinical outcomes in surgically resected primary HCC patients."xsd:string
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http://purl.uniprot.org/citations/18322954http://purl.uniprot.org/core/author"Choi B.O."xsd:string
http://purl.uniprot.org/citations/18322954http://purl.uniprot.org/core/author"Jirtle R.L."xsd:string
http://purl.uniprot.org/citations/18322954http://purl.uniprot.org/core/author"Hong S.C."xsd:string
http://purl.uniprot.org/citations/18322954http://purl.uniprot.org/core/author"Jang H.S."xsd:string
http://purl.uniprot.org/citations/18322954http://purl.uniprot.org/core/author"Ha W.S."xsd:string
http://purl.uniprot.org/citations/18322954http://purl.uniprot.org/core/author"Chai G.Y."xsd:string
http://purl.uniprot.org/citations/18322954http://purl.uniprot.org/core/author"Kang K.M."xsd:string
http://purl.uniprot.org/citations/18322954http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18322954http://purl.uniprot.org/core/name"World J Gastroenterol"xsd:string
http://purl.uniprot.org/citations/18322954http://purl.uniprot.org/core/pages"1394-1398"xsd:string
http://purl.uniprot.org/citations/18322954http://purl.uniprot.org/core/title"Clinical significance of loss of heterozygosity for M6P/IGF2R in patients with primary hepatocellular carcinoma."xsd:string
http://purl.uniprot.org/citations/18322954http://purl.uniprot.org/core/volume"14"xsd:string
http://purl.uniprot.org/citations/18322954http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18322954
http://purl.uniprot.org/citations/18322954http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18322954
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