| http://purl.uniprot.org/citations/18323529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18323529 | http://www.w3.org/2000/01/rdf-schema#comment | "Myocardial infarction, stroke, and venous thromboembolism are characterized by oxygen deprivation. In hypoxia, biological responses are activated that evoke tissue damage. Rapid activation of early growth response-1 in hypoxia upregulates fundamental inflammatory and prothrombotic stress genes. We probed the mechanisms mediating regulation of early growth response-1 and demonstrate that hypoxia stimulates brisk generation of advanced glycation end products (AGEs) by endothelial cells. Via AGE interaction with their chief signaling receptor, RAGE, membrane translocation of protein kinase C-betaII occurs, provoking phosphorylation of c-Jun NH(2)-terminal kinase and increased transcription of early growth response-1 and its downstream target genes. These findings identify RAGE as a master regulator of tissue stress elicited by hypoxia and highlight this receptor as a central therapeutic target to suppress the tissue injury-provoking effects of oxygen deprivation."xsd:string |
| http://purl.uniprot.org/citations/18323529 | http://purl.org/dc/terms/identifier | "doi:10.1161/circresaha.107.165308"xsd:string |
| http://purl.uniprot.org/citations/18323529 | http://purl.uniprot.org/core/author | "Kong L."xsd:string |
| http://purl.uniprot.org/citations/18323529 | http://purl.uniprot.org/core/author | "Yan S.F."xsd:string |
| http://purl.uniprot.org/citations/18323529 | http://purl.uniprot.org/core/author | "Qu W."xsd:string |
| http://purl.uniprot.org/citations/18323529 | http://purl.uniprot.org/core/author | "Chang J.S."xsd:string |
| http://purl.uniprot.org/citations/18323529 | http://purl.uniprot.org/core/author | "Schmidt A.M."xsd:string |
| http://purl.uniprot.org/citations/18323529 | http://purl.uniprot.org/core/author | "Wendt T."xsd:string |
| http://purl.uniprot.org/citations/18323529 | http://purl.uniprot.org/core/author | "Zou Y.S."xsd:string |
| http://purl.uniprot.org/citations/18323529 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18323529 | http://purl.uniprot.org/core/name | "Circ Res"xsd:string |
| http://purl.uniprot.org/citations/18323529 | http://purl.uniprot.org/core/pages | "905-913"xsd:string |
| http://purl.uniprot.org/citations/18323529 | http://purl.uniprot.org/core/title | "Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end products."xsd:string |
| http://purl.uniprot.org/citations/18323529 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/18323529 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18323529 |
| http://purl.uniprot.org/citations/18323529 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18323529 |
| http://purl.uniprot.org/uniprot/P08046#attribution-5490ED0FE1B8E2E59FF62772B05FB2B4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18323529 |
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| http://purl.uniprot.org/uniprot/P28867#attribution-5490ED0FE1B8E2E59FF62772B05FB2B4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18323529 |
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