DESCRIBE <http://purl.uniprot.org/citations/18325919>

Subject	Predicate	Object
http://purl.uniprot.org/citations/18325919	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18325919	http://www.w3.org/2000/01/rdf-schema#comment	" Background Kallikreins, a subgroup of the serine protease enzyme family, are considered important prognostic biomarkers in cancer. Here, we sought to determine the prognostic value of kallikrein 7 (hk7) in ovarian cancer using a novel method of compartmentalized in situ protein analysis. Patients and methods A tissue array composed of 150 advanced-stage ovarian cancers, uniformly treated with surgical debulking followed by platinum-paclitaxel (Taxol) combination chemotherapy, was constructed. For evaluation of kallikrein 7 protein expression, we used an immunofluorescence-based method of automated in situ quantitative measurement of protein analysis (AQUA). Results Mean follow-up time of the cohort was 34.35 months. One hundred and twenty eight of 150 cases had sufficient tissue for AQUA. In univariate survival analysis, low tumor hk7 expression was associated with better outcome for overall survival (OS) and disease-free survival in 3 years (P values 0.032 and 0.037, respectively). In multivariate survival analysis, adjusting for well-characterized prognostic variables, low tumor hk7 expression level was the most significant predictor variable for OS (95% confidence interval 0.125-0.729, P = 0.007). Conclusions High tumor hk7 protein expression is associated with inferior patient outcome in ovarian cancer. hk7 may represent a promising prognostic factor in ovarian cancer."xsd:string
http://purl.uniprot.org/citations/18325919	http://purl.org/dc/terms/identifier	"doi:10.1093/annonc/mdn035"xsd:string
http://purl.uniprot.org/citations/18325919	http://purl.uniprot.org/core/author	"Diamandis E.P."xsd:string
http://purl.uniprot.org/citations/18325919	http://purl.uniprot.org/core/author	"Scorilas A."xsd:string
http://purl.uniprot.org/citations/18325919	http://purl.uniprot.org/core/author	"Kowalski D."xsd:string
http://purl.uniprot.org/citations/18325919	http://purl.uniprot.org/core/author	"Camp R."xsd:string
http://purl.uniprot.org/citations/18325919	http://purl.uniprot.org/core/author	"Dimopoulos M.A."xsd:string
http://purl.uniprot.org/citations/18325919	http://purl.uniprot.org/core/author	"Psyrri A."xsd:string
http://purl.uniprot.org/citations/18325919	http://purl.uniprot.org/core/author	"Markakis S."xsd:string
http://purl.uniprot.org/citations/18325919	http://purl.uniprot.org/core/author	"Kountourakis P."xsd:string
http://purl.uniprot.org/citations/18325919	http://purl.uniprot.org/core/date	"2008"xsd:gYear
http://purl.uniprot.org/citations/18325919	http://purl.uniprot.org/core/name	"Ann Oncol"xsd:string
http://purl.uniprot.org/citations/18325919	http://purl.uniprot.org/core/pages	"1271-1277"xsd:string
http://purl.uniprot.org/citations/18325919	http://purl.uniprot.org/core/title	"Human tissue kallikrein 7, a novel biomarker for advanced ovarian carcinoma using a novel in situ quantitative method of protein expression."xsd:string
http://purl.uniprot.org/citations/18325919	http://purl.uniprot.org/core/volume	"19"xsd:string
http://purl.uniprot.org/citations/18325919	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/18325919
http://purl.uniprot.org/citations/18325919	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/18325919
http://purl.uniprot.org/uniprot/#_A0A024R4H6-mappedCitation-18325919	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18325919
http://purl.uniprot.org/uniprot/#_A0A2H4GDB2-mappedCitation-18325919	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18325919
http://purl.uniprot.org/uniprot/#_A0A2H4GDB6-mappedCitation-18325919	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18325919
http://purl.uniprot.org/uniprot/#_B4DHX9-mappedCitation-18325919	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18325919
http://purl.uniprot.org/uniprot/#_B8K1J4-mappedCitation-18325919	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18325919
http://purl.uniprot.org/uniprot/#_P49862-mappedCitation-18325919	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18325919
http://purl.uniprot.org/uniprot/#_Q6DTY1-mappedCitation-18325919	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/18325919