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| Subject | Predicate | Object |
|---|---|---|
| http://purl.uniprot.org/citations/18325999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18325999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18325999 | http://www.w3.org/2000/01/rdf-schema#comment | "beta 1-3-Adrenoreceptor (AR)-deficient mice are unable to regulate energy expenditure and develop diet-induced obesity on a high-fat diet. We determined previously that beta2-AR agonist treatment activated expression of the mRNA encoding the orphan nuclear receptor, NOR-1, in muscle cells and plantaris muscle. Here we show that beta2-AR agonist treatment significantly and transiently activated the expression of NOR-1 (and the other members of the NR4A subgroup) in slow-twitch oxidative soleus muscle and fast-twitch glycolytic tibialis anterior muscle. The activation induced by beta-adrenergic signaling is consistent with the involvement of protein kinase A, MAPK, and phosphorylation of cAMP response element-binding protein. Stable cell lines transfected with a silent interfering RNA targeting NOR-1 displayed decreased palmitate oxidation and lactate accumulation. In concordance with these observations, ATP production in the NOR-1 silent interfering RNA (but not control)-transfected cells was resistant to (azide-mediated) inhibition of oxidative metabolism and expressed significantly higher levels of hypoxia inducible factor-1alpha. In addition, we observed the repression of genes that promote fatty acid oxidation (peroxisomal proliferator-activated receptor-gamma coactivator-1alpha/beta and lipin-1alpha) and trichloroacetic acid cycle-mediated carbohydrate (pyruvate) oxidation [pyruvate dehydrogenase phosphatase 1 regulatory and catalytic subunits (pyruvate dehydrogenase phosphatases-1r and -c)]. Furthermore, we observed that beta2-AR agonist administration in mouse skeletal muscle induced the expression of genes that activate fatty acid oxidation and modulate pyruvate use, including PGC-1alpha, lipin-1alpha, FOXO1, and PDK4. Finally, we demonstrate that NOR-1 is recruited to the lipin-1alpha and PDK-4 promoters, and this is consistent with NOR-1-mediated regulation of these genes. In conclusion, NOR-1 is necessary for oxidative metabolism in skeletal muscle."xsd:string |
| http://purl.uniprot.org/citations/18325999 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2007-1202"xsd:string |
| http://purl.uniprot.org/citations/18325999 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2007-1202"xsd:string |
| http://purl.uniprot.org/citations/18325999 | http://purl.uniprot.org/core/author | "Lynch G.S."xsd:string |
| http://purl.uniprot.org/citations/18325999 | http://purl.uniprot.org/core/author | "Lynch G.S."xsd:string |
| http://purl.uniprot.org/citations/18325999 | http://purl.uniprot.org/core/author | "Ryall J.G."xsd:string |
| http://purl.uniprot.org/citations/18325999 | http://purl.uniprot.org/core/author | "Ryall J.G."xsd:string |
| http://purl.uniprot.org/citations/18325999 | http://purl.uniprot.org/core/author | "Muscat G.E."xsd:string |
| http://purl.uniprot.org/citations/18325999 | http://purl.uniprot.org/core/author | "Muscat G.E."xsd:string |
| http://purl.uniprot.org/citations/18325999 | http://purl.uniprot.org/core/author | "Raichur S."xsd:string |
| http://purl.uniprot.org/citations/18325999 | http://purl.uniprot.org/core/author | "Raichur S."xsd:string |
| http://purl.uniprot.org/citations/18325999 | http://purl.uniprot.org/core/author | "Myers S.A."xsd:string |
| http://purl.uniprot.org/citations/18325999 | http://purl.uniprot.org/core/author | "Myers S.A."xsd:string |
| http://purl.uniprot.org/citations/18325999 | http://purl.uniprot.org/core/author | "Pearen M.A."xsd:string |
| http://purl.uniprot.org/citations/18325999 | http://purl.uniprot.org/core/author | "Pearen M.A."xsd:string |
| http://purl.uniprot.org/citations/18325999 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18325999 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18325999 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/18325999 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/18325999 | http://purl.uniprot.org/core/pages | "2853-2865"xsd:string |
| http://purl.uniprot.org/citations/18325999 | http://purl.uniprot.org/core/pages | "2853-2865"xsd:string |
| http://purl.uniprot.org/citations/18325999 | http://purl.uniprot.org/core/title | "The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle."xsd:string |
| http://purl.uniprot.org/citations/18325999 | http://purl.uniprot.org/core/title | "The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle."xsd:string |