| http://purl.uniprot.org/citations/18327081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18327081 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectivesTissue kallikrein is a major kinin-forming enzyme involved in artery and kidney functions. Urinary tissue kallikrein activity (UKLKa) reflects renal tissue kallikrein activity and depends on Na and K intake, and genetic factors, especially the tissue kallikrein-inactivating polymorphism, R53H. The effect of these factors on the level of kinin peptides is, however, not known. Moreover, a circulating form of tissue kallikrein is present in human plasma but its origin and regulation are unknown.MethodsWe used a crossover study to investigate UKLKa, plasma tissue kallikrein (pTK), and urinary kallidin peptides and metabolites (Uki) in 10 R53H and 30 R53R normotensive male subjects randomly assigned to either a 1-week low Na-high K or a high Na-low K diet.ResultsUKLKa was 50-60% lower in R53H than R53R subjects and was increased by the low Na-high K diet. pTK was also 45-55% lower in R53H than R53R subjects and was increased by the low Na-high K diet. Uki was slightly but significantly higher under the low Na-high K than the high Na-low K diet, but did not differ between genotypes.ConclusionThese observations indicate that pTK levels are genetically determined and regulated by Na and K diet, in parallel with UKLKa; this suggests that circulating tissue kallikrein originates mainly from the kidney, and can contribute to circulatory adaptation to dietary ions. Uki is influenced by the Na and K diet, suggesting that kinins participate in renal adaptation to ion intake, but do not quantitatively reflect tissue kallikrein activity in urine, or presumably, in the kidney."xsd:string |
| http://purl.uniprot.org/citations/18327081 | http://purl.org/dc/terms/identifier | "doi:10.1097/hjh.0b013e3282f4d1fa"xsd:string |
| http://purl.uniprot.org/citations/18327081 | http://purl.uniprot.org/core/author | "Alhenc-Gelas F."xsd:string |
| http://purl.uniprot.org/citations/18327081 | http://purl.uniprot.org/core/author | "Azizi M."xsd:string |
| http://purl.uniprot.org/citations/18327081 | http://purl.uniprot.org/core/author | "Campbell D.J."xsd:string |
| http://purl.uniprot.org/citations/18327081 | http://purl.uniprot.org/core/author | "Emanueli C."xsd:string |
| http://purl.uniprot.org/citations/18327081 | http://purl.uniprot.org/core/author | "Peyrard S."xsd:string |
| http://purl.uniprot.org/citations/18327081 | http://purl.uniprot.org/core/author | "Maddedu P."xsd:string |
| http://purl.uniprot.org/citations/18327081 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18327081 | http://purl.uniprot.org/core/name | "J Hypertens"xsd:string |
| http://purl.uniprot.org/citations/18327081 | http://purl.uniprot.org/core/pages | "714-720"xsd:string |
| http://purl.uniprot.org/citations/18327081 | http://purl.uniprot.org/core/title | "Genetic and dietary control of plasma tissue kallikrein secretion and urinary kinins exretion in man."xsd:string |
| http://purl.uniprot.org/citations/18327081 | http://purl.uniprot.org/core/volume | "26"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A1L2BPJ2-mappedCitation-18327081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18327081 |
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| http://purl.uniprot.org/uniprot/#_P06870-mappedCitation-18327081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18327081 |
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| http://purl.uniprot.org/uniprot/#_Q6T776-mappedCitation-18327081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18327081 |
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