| http://purl.uniprot.org/citations/18327259 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18327259 | http://www.w3.org/2000/01/rdf-schema#comment | "The genomic region encoding the miR-17-92 microRNA (miRNA) cluster is often amplified in lymphoma and other cancers, and cancer cells carrying this amplification have higher expression of miRNA in this cluster. Retroviral expression of miR-17-92 accelerates c-Myc-induced lymphoma development, but precisely how higher expression of miR-17-92 promotes lymphomagenesis remains unclear. Here we generated mice with higher expression of miR-17-92 in lymphocytes. These mice developed lymphoproliferative disease and autoimmunity and died prematurely. Lymphocytes from these mice showed more proliferation and less activation-induced cell death. The miR-17-92 miRNA suppressed expression of the tumor suppressor PTEN and the proapoptotic protein Bim. This mechanism probably contributed to the lymphoproliferative disease and autoimmunity of miR-17-92-transgenic mice and contributes to lymphoma development in patients with amplifications of the miR-17-92 coding region."xsd:string |
| http://purl.uniprot.org/citations/18327259 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1575"xsd:string |
| http://purl.uniprot.org/citations/18327259 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/18327259 | http://purl.uniprot.org/core/author | "Zhang B."xsd:string |
| http://purl.uniprot.org/citations/18327259 | http://purl.uniprot.org/core/author | "Xiao C."xsd:string |
| http://purl.uniprot.org/citations/18327259 | http://purl.uniprot.org/core/author | "Kutok J.L."xsd:string |
| http://purl.uniprot.org/citations/18327259 | http://purl.uniprot.org/core/author | "Henderson J.M."xsd:string |
| http://purl.uniprot.org/citations/18327259 | http://purl.uniprot.org/core/author | "Rajewsky K."xsd:string |
| http://purl.uniprot.org/citations/18327259 | http://purl.uniprot.org/core/author | "Srinivasan L."xsd:string |
| http://purl.uniprot.org/citations/18327259 | http://purl.uniprot.org/core/author | "Calado D.P."xsd:string |
| http://purl.uniprot.org/citations/18327259 | http://purl.uniprot.org/core/author | "Patterson H.C."xsd:string |
| http://purl.uniprot.org/citations/18327259 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18327259 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/18327259 | http://purl.uniprot.org/core/pages | "405-414"xsd:string |
| http://purl.uniprot.org/citations/18327259 | http://purl.uniprot.org/core/title | "Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/18327259 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/18327259 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18327259 |
| http://purl.uniprot.org/citations/18327259 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18327259 |
| http://purl.uniprot.org/uniprot/#_A0A024QYR9-mappedCitation-18327259 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18327259 |
| http://purl.uniprot.org/uniprot/#_A0A1V0DNR6-mappedCitation-18327259 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18327259 |
| http://purl.uniprot.org/uniprot/#_A0A6G6A824-mappedCitation-18327259 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18327259 |
| http://purl.uniprot.org/uniprot/#_A0A6G7SEK5-mappedCitation-18327259 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18327259 |
| http://purl.uniprot.org/uniprot/#_A0A6G7SF19-mappedCitation-18327259 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18327259 |
| http://purl.uniprot.org/uniprot/#_O54918-mappedCitation-18327259 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18327259 |