| http://purl.uniprot.org/citations/18327588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18327588 | http://www.w3.org/2000/01/rdf-schema#comment | "Membrane traffic is tightly regulated and the Rab protein family of small GTPases plays a central role in this regulation. One member of this family is the Saccharomyces cerevisae protein Ypt6. To search for new genes interacting with Ypt6-related pathways, we performed a genetic screen for high copy suppressors of ypt6Delta temperature sensitivity at 35 degrees C. Among the suppressors, MYR1 was also able to suppress the temperature sensitive mutant lacking Ric1, a subunit of the Ypt6 guanine exchanging factor complex Ric1/Rgp1. Myr1 is characterized by a coiled coil region and a GYF domain, a protein module binding proline-rich sequences. Myr1 is able to bind membranes but is also associated with larger structures insoluble in Triton X-100. By immunofluorescence, Myr1 shows a network-like pattern as well as small foci. Overexpression of Myr1 influences nuclear envelope morphology and high levels are lethal. This lethality is rescued when the N-terminal region, containing the GYF domain, is deleted. The transcription profile of a myr1Delta strain shows effects on genes involved in nuclear migration, Ras signalling and transcription. Taken together, these results suggest that Myr1 is a novel factor linked to the secretory pathway and important cellular regulatory mechanisms."xsd:string |
| http://purl.uniprot.org/citations/18327588 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00294-008-0183-0"xsd:string |
| http://purl.uniprot.org/citations/18327588 | http://purl.uniprot.org/core/author | "Georgiev A."xsd:string |
| http://purl.uniprot.org/citations/18327588 | http://purl.uniprot.org/core/author | "Mutvei A."xsd:string |
| http://purl.uniprot.org/citations/18327588 | http://purl.uniprot.org/core/author | "Berrez J.M."xsd:string |
| http://purl.uniprot.org/citations/18327588 | http://purl.uniprot.org/core/author | "Leipus A."xsd:string |
| http://purl.uniprot.org/citations/18327588 | http://purl.uniprot.org/core/author | "Olsson I."xsd:string |
| http://purl.uniprot.org/citations/18327588 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18327588 | http://purl.uniprot.org/core/name | "Curr Genet"xsd:string |
| http://purl.uniprot.org/citations/18327588 | http://purl.uniprot.org/core/pages | "235-247"xsd:string |
| http://purl.uniprot.org/citations/18327588 | http://purl.uniprot.org/core/title | "Characterization of MYR1, a dosage suppressor of YPT6 and RIC1 deficient mutants."xsd:string |
| http://purl.uniprot.org/citations/18327588 | http://purl.uniprot.org/core/volume | "53"xsd:string |
| http://purl.uniprot.org/citations/18327588 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18327588 |
| http://purl.uniprot.org/citations/18327588 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18327588 |
| http://purl.uniprot.org/uniprot/Q02875#attribution-59F5C3EE569AAEA1A65255AA5EA3CB61 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18327588 |
| http://purl.uniprot.org/uniprot/Q02875#attribution-E909E0E03DA680F5E426B0E595191EDD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18327588 |
| http://purl.uniprot.org/uniprot/#_Q02875-mappedCitation-18327588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18327588 |
| http://purl.uniprot.org/uniprot/Q02875 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18327588 |