| http://purl.uniprot.org/citations/18328742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18328742 | http://www.w3.org/2000/01/rdf-schema#comment | "Costimulatory signals are critical to T cell activation, but how their effects are mediated remains incompletely characterized. Here, we demonstrate that locally produced C5a and C3a anaphylatoxins interacting with their G protein-coupled receptors (GPCRs), C5aR and C3aR, on APCs and T cells both upstream and downstream of CD28 and CD40L signaling are integrally involved in T cell proliferation and differentiation. Disabling these interactions reduced MHC class II and costimulatory-molecule expression and dramatically diminished T cell responses. Importantly, impaired T cell activation by Cd80-/-Cd86-/- and Cd40-/-APCs was reconstituted by added C5a or C3a. C5aR and C3aR mediated their effects via PI-3 kinase-gamma-dependent AKT phosphorylation, providing a link between GPCR signaling, CD28 costimulation, and T cell survival. These local paracrine and autocrine interactions thus operate constitutively in naive T cells to maintain viability, and their amplification by cognate APC partners thus is critical to T cell costimulation."xsd:string |
| http://purl.uniprot.org/citations/18328742 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2008.02.001"xsd:string |
| http://purl.uniprot.org/citations/18328742 | http://purl.uniprot.org/core/author | "Huang D."xsd:string |
| http://purl.uniprot.org/citations/18328742 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/18328742 | http://purl.uniprot.org/core/author | "An F."xsd:string |
| http://purl.uniprot.org/citations/18328742 | http://purl.uniprot.org/core/author | "Heeger P.S."xsd:string |
| http://purl.uniprot.org/citations/18328742 | http://purl.uniprot.org/core/author | "Shapiro V.S."xsd:string |
| http://purl.uniprot.org/citations/18328742 | http://purl.uniprot.org/core/author | "Medof M.E."xsd:string |
| http://purl.uniprot.org/citations/18328742 | http://purl.uniprot.org/core/author | "Dubyak G.R."xsd:string |
| http://purl.uniprot.org/citations/18328742 | http://purl.uniprot.org/core/author | "Muqim N."xsd:string |
| http://purl.uniprot.org/citations/18328742 | http://purl.uniprot.org/core/author | "Lalli P.N."xsd:string |
| http://purl.uniprot.org/citations/18328742 | http://purl.uniprot.org/core/author | "Strainic M.G."xsd:string |
| http://purl.uniprot.org/citations/18328742 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18328742 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/18328742 | http://purl.uniprot.org/core/pages | "425-435"xsd:string |
| http://purl.uniprot.org/citations/18328742 | http://purl.uniprot.org/core/title | "Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells."xsd:string |
| http://purl.uniprot.org/citations/18328742 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/18328742 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18328742 |
| http://purl.uniprot.org/citations/18328742 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18328742 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUU3-mappedCitation-18328742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18328742 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GT01-mappedCitation-18328742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18328742 |
| http://purl.uniprot.org/uniprot/#_A2A5L7-mappedCitation-18328742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18328742 |
| http://purl.uniprot.org/uniprot/#_A0A0X9RAD7-mappedCitation-18328742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18328742 |
| http://purl.uniprot.org/uniprot/#_E1APH6-mappedCitation-18328742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18328742 |