| http://purl.uniprot.org/citations/18329299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18329299 | http://www.w3.org/2000/01/rdf-schema#comment | "The resting membrane potential of the human erythrocyte is largely determined by a constitutive Cl(-) conductance approximately 100-fold greater than the resting cation conductance. The 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS)-sensitive electroneutral Cl(-) transport mediated by the human erythroid Cl(-)/HCO(3)(-) exchanger, AE1 (SLC4A1, band 3) is >10,000-fold greater than can be accounted for by the Cl(-) conductance of the red cell. The molecular identities of conductive anion pathways across the red cell membrane remain poorly defined. We have examined red cell Cl(-) conductance in the Ae1(-/-) mouse as a genetic test of the hypothesis that Ae1 mediates DIDS-sensitive Cl(-) conductance in mouse red cells. We report here that wildtype mouse red cell membrane potential resembles that of human red cells in the predominance of its Cl(-) conductance. We show with four technical approaches that the DIDS-sensitive component of erythroid Cl(-) conductance is reduced or absent from Ae1(-/-) red cells. These results are consistent with the hypothesis that the Ae1 anion exchanger polypeptide can operate infrequently in a conductive mode. However, the fragile red cell membrane of the Ae1(-/-) mouse red cell exhibits reduced abundance or loss of multiple polypeptides. Thus, loss of one or more distinct, DIDS-sensitive anion channel polypeptide(s) from the Ae1(-/-) red cell membrane cannot be ruled out as an explanation for the reduced DIDS-sensitive anion conductance."xsd:string |
| http://purl.uniprot.org/citations/18329299 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bcmd.2008.01.002"xsd:string |
| http://purl.uniprot.org/citations/18329299 | http://purl.uniprot.org/core/author | "Alper S.L."xsd:string |
| http://purl.uniprot.org/citations/18329299 | http://purl.uniprot.org/core/author | "Brugnara C."xsd:string |
| http://purl.uniprot.org/citations/18329299 | http://purl.uniprot.org/core/author | "Peters L.L."xsd:string |
| http://purl.uniprot.org/citations/18329299 | http://purl.uniprot.org/core/author | "Vandorpe D.H."xsd:string |
| http://purl.uniprot.org/citations/18329299 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18329299 | http://purl.uniprot.org/core/name | "Blood Cells Mol Dis"xsd:string |
| http://purl.uniprot.org/citations/18329299 | http://purl.uniprot.org/core/pages | "22-34"xsd:string |
| http://purl.uniprot.org/citations/18329299 | http://purl.uniprot.org/core/title | "Reduced DIDS-sensitive chloride conductance in Ae1-/- mouse erythrocytes."xsd:string |
| http://purl.uniprot.org/citations/18329299 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/18329299 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18329299 |
| http://purl.uniprot.org/citations/18329299 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18329299 |
| http://purl.uniprot.org/uniprot/#_Q3TZG9-mappedCitation-18329299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18329299 |
| http://purl.uniprot.org/uniprot/#_Q3TZJ1-mappedCitation-18329299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18329299 |
| http://purl.uniprot.org/uniprot/#_P04919-mappedCitation-18329299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18329299 |
| http://purl.uniprot.org/uniprot/#_Q3TZ12-mappedCitation-18329299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18329299 |
| http://purl.uniprot.org/uniprot/#_Q3TZ29-mappedCitation-18329299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18329299 |
| http://purl.uniprot.org/uniprot/#_Q3TAJ4-mappedCitation-18329299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18329299 |
| http://purl.uniprot.org/uniprot/#_Q3TNH7-mappedCitation-18329299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18329299 |
| http://purl.uniprot.org/uniprot/#_Q3TNL6-mappedCitation-18329299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18329299 |
| http://purl.uniprot.org/uniprot/#_Q53ZN9-mappedCitation-18329299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18329299 |
| http://purl.uniprot.org/uniprot/#_Q3U065-mappedCitation-18329299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18329299 |
| http://purl.uniprot.org/uniprot/Q3U065 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18329299 |