| http://purl.uniprot.org/citations/18329615 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18329615 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18329615 | http://www.w3.org/2000/01/rdf-schema#comment | "Symptoms of T cell hyperactivation shape the course and outcome of HIV-1 infection, but the mechanism(s) underlying this chronic immune activation are not well understood. We find that the viral transactivator Tat promotes hyperactivation of T cells by blocking the nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase SIRT1. Tat directly interacts with the deacetylase domain of SIRT1 and blocks the ability of SIRT1 to deacetylate lysine 310 in the p65 subunit of NF-kappaB. Because acetylated p65 is more active as a transcription factor, Tat hyperactivates the expression of NF-kappaB-responsive genes, a function lost in SIRT1-/-cells. These results support a model where the normal function of SIRT1 as a negative regulator of T cell activation is suppressed by Tat during HIV infection. These events likely contribute to the state of immune cell hyperactivation found in HIV-infected individuals."xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2008.02.002"xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2008.02.002"xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.uniprot.org/core/author | "Marmorstein R."xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.uniprot.org/core/author | "Marmorstein R."xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.uniprot.org/core/author | "Ott M."xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.uniprot.org/core/author | "Ott M."xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.uniprot.org/core/author | "Brent M.M."xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.uniprot.org/core/author | "Brent M.M."xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.uniprot.org/core/author | "Greene W.C."xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.uniprot.org/core/author | "Greene W.C."xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.uniprot.org/core/author | "Kwon H.S."xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.uniprot.org/core/author | "Kwon H.S."xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.uniprot.org/core/author | "Schnolzer M."xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.uniprot.org/core/author | "Schnolzer M."xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.uniprot.org/core/author | "McBurney M.W."xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.uniprot.org/core/author | "McBurney M.W."xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.uniprot.org/core/author | "Chen L.F."xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.uniprot.org/core/author | "Chen L.F."xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.uniprot.org/core/author | "Getachew R."xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.uniprot.org/core/author | "Getachew R."xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.uniprot.org/core/author | "Jayakumar P."xsd:string |
| http://purl.uniprot.org/citations/18329615 | http://purl.uniprot.org/core/author | "Jayakumar P."xsd:string |