| http://purl.uniprot.org/citations/18330707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18330707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18330707 | http://www.w3.org/2000/01/rdf-schema#comment | "ISG12a is one of the most highly induced genes following treatment of cells with type I interferons (IFNs). The encoded protein belongs to a family of poorly characterized, low molecular weight IFN-inducible proteins that includes 6-16 (G1P3), 1-8U (IFITM3), and 1-8D (IFITM2). Our studies demonstrate that the ISG12a protein associates with or inserts into the mitochondrial membrane. Transient expression of ISG12a led to decreased viable cell numbers and enhanced sensitivity to DNA-damage induced apoptosis, effects that were blocked by Bcl-2 co-expression or treatment with a pan-caspase inhibitor. ISG12a enhanced etoposide induced cytochrome c release, Bax activation and loss of mitochondrial membrane potential. siRNA-mediated inhibition of ectopic ISG12a protein expression prevented the sensitization to etoposide-induced apoptosis and also decreased the ability of IFN-beta pretreatment to sensitize cells to etoposide, thereby demonstrating a role for ISG12a in this process. These data suggest that ISG12a contributes to IFN-dependent perturbation of normal mitochondrial function, thus adding ISG12a to a growing list of IFN-induced proteins that impact cellular apoptosis."xsd:string |
| http://purl.uniprot.org/citations/18330707 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10495-008-0190-0"xsd:string |
| http://purl.uniprot.org/citations/18330707 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10495-008-0190-0"xsd:string |
| http://purl.uniprot.org/citations/18330707 | http://purl.uniprot.org/core/author | "Leaman D.W."xsd:string |
| http://purl.uniprot.org/citations/18330707 | http://purl.uniprot.org/core/author | "Leaman D.W."xsd:string |
| http://purl.uniprot.org/citations/18330707 | http://purl.uniprot.org/core/author | "Rosebeck S."xsd:string |
| http://purl.uniprot.org/citations/18330707 | http://purl.uniprot.org/core/author | "Rosebeck S."xsd:string |
| http://purl.uniprot.org/citations/18330707 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18330707 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18330707 | http://purl.uniprot.org/core/name | "Apoptosis"xsd:string |
| http://purl.uniprot.org/citations/18330707 | http://purl.uniprot.org/core/name | "Apoptosis"xsd:string |
| http://purl.uniprot.org/citations/18330707 | http://purl.uniprot.org/core/pages | "562-572"xsd:string |
| http://purl.uniprot.org/citations/18330707 | http://purl.uniprot.org/core/pages | "562-572"xsd:string |
| http://purl.uniprot.org/citations/18330707 | http://purl.uniprot.org/core/title | "Mitochondrial localization and pro-apoptotic effects of the interferon-inducible protein ISG12a."xsd:string |
| http://purl.uniprot.org/citations/18330707 | http://purl.uniprot.org/core/title | "Mitochondrial localization and pro-apoptotic effects of the interferon-inducible protein ISG12a."xsd:string |
| http://purl.uniprot.org/citations/18330707 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/18330707 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/18330707 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18330707 |
| http://purl.uniprot.org/citations/18330707 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18330707 |
| http://purl.uniprot.org/citations/18330707 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18330707 |
| http://purl.uniprot.org/citations/18330707 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18330707 |
| http://purl.uniprot.org/uniprot/P40305 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/18330707 |
| http://purl.uniprot.org/uniprot/P40305#attribution-94ED0776076D7604AB4D007B0CBF73D8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18330707 |