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http://purl.uniprot.org/citations/18332066http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18332066http://www.w3.org/2000/01/rdf-schema#comment"

Background

Cytomegalovirus (CMV) infection in transplant patients with special risk factors remains a major hazard. CMV-seronegative recipients with seropositive donors have the highest risk of developing acute CMV disease. We suggest that the HLA-type may influence the occurrence and the severity of primary CMV infection of these recipients and the measurement of the special HLA-types may be useful in the prediction of acute infection.

Methods

Since 1999 1213 cadaver kidney transplantations have been performed in our clinic. 163 of 1213 recipients were CMV-seronegative (13%) and 129 of them received the kidney from seropositive donors. All 129 patients received CMV infection prophylaxis. Of 129 CMV-seronegative patients 49 developed acute CMV infection (38%) during the first posttransplant year. CMV infection was diagnosed by CMV antigenemia test and serologic measurements (ELISA). The particular HLA-genotypes of the recipients were studied before the transplantation. The occurrence and the severity of CMV infection was investigated in association with HLA-types.

Results

We found different acute CMV infection distribution in the careers and non-careers of investigated HLA-types: HLA-A2, HLA-B12, HLA-Cw7, HLA-DR6 and HLA-DR11, but the differences were not significant in these HLA-types (P = 0.26, P = 0.37, P = 0.83, P = 0.07 and P = 0.37). While investigating HLA-DQ3, we found that of 68 DQ3-positive patients 32 (47%), of 61 DQ3-negative patients 17 (28%) had acute CMV infection and this difference was found to be significant. This result was confirmed by univariate and multivariate Cox Regression (P = 0.001) and the appropriate significance level was considered by Bonferroni correction.

Conclusions

HLA-DQ3 was found to be an independent predictor of CMV infection. Our data suggest that patients positive for HLA-DQ3 are more susceptible to CMV infection than a comparable group of patients negative for HLA-DQ3. This result was not due to rejection and/or treatment for rejection and was not influenced by induction therapy. Although we found more symptomatic infections among DQ3+ patients the difference was not significant (P = 0.19). Comparing the gender proportion among all 1213 kidney recipients and among CMV-seronegative recipients we found that the proportion of males is significantly higher among CMV-seronegative recipients (P < 0.001)."xsd:string
http://purl.uniprot.org/citations/18332066http://purl.org/dc/terms/identifier"doi:10.1093/ndt/gfn111"xsd:string
http://purl.uniprot.org/citations/18332066http://purl.uniprot.org/core/author"Peter A."xsd:string
http://purl.uniprot.org/citations/18332066http://purl.uniprot.org/core/author"Korbonits M."xsd:string
http://purl.uniprot.org/citations/18332066http://purl.uniprot.org/core/author"Rajczy K."xsd:string
http://purl.uniprot.org/citations/18332066http://purl.uniprot.org/core/author"Varga M."xsd:string
http://purl.uniprot.org/citations/18332066http://purl.uniprot.org/core/author"Fazakas J."xsd:string
http://purl.uniprot.org/citations/18332066http://purl.uniprot.org/core/author"Sarvary E."xsd:string
http://purl.uniprot.org/citations/18332066http://purl.uniprot.org/core/author"Jaray J."xsd:string
http://purl.uniprot.org/citations/18332066http://purl.uniprot.org/core/author"Kobori L."xsd:string
http://purl.uniprot.org/citations/18332066http://purl.uniprot.org/core/author"Remport A."xsd:string
http://purl.uniprot.org/citations/18332066http://purl.uniprot.org/core/author"Hidvegi M."xsd:string
http://purl.uniprot.org/citations/18332066http://purl.uniprot.org/core/author"Telkes G."xsd:string
http://purl.uniprot.org/citations/18332066http://purl.uniprot.org/core/author"Toronyi E."xsd:string
http://purl.uniprot.org/citations/18332066http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18332066http://purl.uniprot.org/core/name"Nephrol Dial Transplant"xsd:string
http://purl.uniprot.org/citations/18332066http://purl.uniprot.org/core/pages"2673-2678"xsd:string
http://purl.uniprot.org/citations/18332066http://purl.uniprot.org/core/title"HLA-DQ3 is a probable risk factor for CMV infection in high-risk kidney transplant patients."xsd:string
http://purl.uniprot.org/citations/18332066http://purl.uniprot.org/core/volume"23"xsd:string
http://purl.uniprot.org/citations/18332066http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18332066
http://purl.uniprot.org/citations/18332066http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18332066
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-18332066http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18332066
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-18332066http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18332066
http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-18332066http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18332066
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