| http://purl.uniprot.org/citations/18332134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18332134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18332134 | http://www.w3.org/2000/01/rdf-schema#comment | "Vascular endothelial growth factor (VEGF) is essential for normal and pathological angiogenesis. However, the signaling pathways linked to gene regulation in VEGF-induced angiogenesis are not fully understood. Here we demonstrate a critical role of protein kinase D (PKD) and histone deacetylase 5 (HDAC5) in VEGF-induced gene expression and angiogenesis. We found that VEGF stimulated HDAC5 phosphorylation and nuclear export in endothelial cells through a VEGF receptor 2-phospholipase Cgamma-protein kinase C-PKD-dependent pathway. We further showed that the PKD-HDAC5 pathway mediated myocyte enhancer factor-2 transcriptional activation and a specific subset of gene expression in response to VEGF, including NR4A1, an orphan nuclear receptor involved in angiogenesis. Specifically, inhibition of PKD by overexpression of the PKD kinase-negative mutant prevents VEGF-induced HDAC5 phosphorylation and nuclear export as well as NR4A1 induction. Moreover, a mutant of HDAC5 specifically deficient in PKD-dependent phosphorylation inhibited VEGF-mediated NR4A1 expression, endothelial cell migration, and in vitro angiogenesis. These findings suggest that the PKD-HDAC5 pathway plays an important role in VEGF regulation of gene transcription and angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/18332134 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m800264200"xsd:string |
| http://purl.uniprot.org/citations/18332134 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m800264200"xsd:string |
| http://purl.uniprot.org/citations/18332134 | http://purl.uniprot.org/core/author | "Hausser A."xsd:string |
| http://purl.uniprot.org/citations/18332134 | http://purl.uniprot.org/core/author | "Hausser A."xsd:string |
| http://purl.uniprot.org/citations/18332134 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/18332134 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/18332134 | http://purl.uniprot.org/core/author | "Wong C."xsd:string |
| http://purl.uniprot.org/citations/18332134 | http://purl.uniprot.org/core/author | "Wong C."xsd:string |
| http://purl.uniprot.org/citations/18332134 | http://purl.uniprot.org/core/author | "Pfizenmaier K."xsd:string |
| http://purl.uniprot.org/citations/18332134 | http://purl.uniprot.org/core/author | "Pfizenmaier K."xsd:string |
| http://purl.uniprot.org/citations/18332134 | http://purl.uniprot.org/core/author | "Olson E.N."xsd:string |
| http://purl.uniprot.org/citations/18332134 | http://purl.uniprot.org/core/author | "Olson E.N."xsd:string |
| http://purl.uniprot.org/citations/18332134 | http://purl.uniprot.org/core/author | "Jin Z.G."xsd:string |
| http://purl.uniprot.org/citations/18332134 | http://purl.uniprot.org/core/author | "Jin Z.G."xsd:string |
| http://purl.uniprot.org/citations/18332134 | http://purl.uniprot.org/core/author | "McKinsey T.A."xsd:string |
| http://purl.uniprot.org/citations/18332134 | http://purl.uniprot.org/core/author | "McKinsey T.A."xsd:string |
| http://purl.uniprot.org/citations/18332134 | http://purl.uniprot.org/core/author | "Ha C.H."xsd:string |
| http://purl.uniprot.org/citations/18332134 | http://purl.uniprot.org/core/author | "Ha C.H."xsd:string |
| http://purl.uniprot.org/citations/18332134 | http://purl.uniprot.org/core/author | "Jhun B.S."xsd:string |
| http://purl.uniprot.org/citations/18332134 | http://purl.uniprot.org/core/author | "Jhun B.S."xsd:string |
| http://purl.uniprot.org/citations/18332134 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18332134 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |