| http://purl.uniprot.org/citations/1833386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1833386 | http://www.w3.org/2000/01/rdf-schema#comment | "A large number of diverse cell surface proteins are anchored to the cell membrane by a glycosylphosphatidylinositol (GPI) anchor. One proposed function for the GPI anchor is that it facilitates the release of the protein from the cell by acting as a target for anchor-specific phospholipases. We and others have discovered that mammalian plasma contains a GPI-specific phospholipase D (GPI-PLD) (Cardoso de Almeida, M. L., Turner, M. J., Stambuk, B. V., and Schenkman, S. (1988) Biochem, Biophys. Res. Commun. 150, 476-482; Davitz, M. A., Hereld, D., Shak, S., Krakow, J., Englund, P. T., and Nussenzweig, V. (1987) Science 238, 81-84; Low, M. G., and Prasad, A. R. S. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 980-984). Because the GPI-PLD recognizes a conserved portion of the anchor, all GPI-anchored proteins are potential substrates for the enzyme. We demonstrate in this communication the production of the plasma GPI-PLD by the islets of Langerhans. GPI-PLD enzymatic activity was found in dog pancreatic microsomes, but not pancreatic juice. Both the pancreatic and plasma enzymes were divalent cation-dependent and had identical substrate specificities. Purified murine islets of Langerhans, as well as alpha and beta cells, contained and released GPI-PLD activity. A GPI-PLD DNA fragment was amplified by polymerase chain reaction from a normal human islet cDNA library; the amplified fragment hybridized with the GPI-PLD cDNA clone. These findings represent the first demonstration of the production of the plasma GPI-PLD by a specific tissue site as well as cell type."xsd:string |
| http://purl.uniprot.org/citations/1833386 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)55185-1"xsd:string |
| http://purl.uniprot.org/citations/1833386 | http://purl.uniprot.org/core/author | "Guo Y."xsd:string |
| http://purl.uniprot.org/citations/1833386 | http://purl.uniprot.org/core/author | "Zhang Y.Y."xsd:string |
| http://purl.uniprot.org/citations/1833386 | http://purl.uniprot.org/core/author | "Davitz M.A."xsd:string |
| http://purl.uniprot.org/citations/1833386 | http://purl.uniprot.org/core/author | "Kochan J.P."xsd:string |
| http://purl.uniprot.org/citations/1833386 | http://purl.uniprot.org/core/author | "Metz C.N."xsd:string |
| http://purl.uniprot.org/citations/1833386 | http://purl.uniprot.org/core/author | "Tsang T.C."xsd:string |
| http://purl.uniprot.org/citations/1833386 | http://purl.uniprot.org/core/author | "Altszuler N."xsd:string |
| http://purl.uniprot.org/citations/1833386 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1833386 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/1833386 | http://purl.uniprot.org/core/pages | "17733-17736"xsd:string |
| http://purl.uniprot.org/citations/1833386 | http://purl.uniprot.org/core/title | "Production of the glycosylphosphatidylinositol-specific phospholipase D by the islets of Langerhans."xsd:string |
| http://purl.uniprot.org/citations/1833386 | http://purl.uniprot.org/core/volume | "266"xsd:string |
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