| http://purl.uniprot.org/citations/18337748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18337748 | http://www.w3.org/2000/01/rdf-schema#comment | "VE-cadherin is an endothelial-specific transmembrane protein concentrated at cell-to-cell adherens junctions. Besides promoting cell adhesion and controlling vascular permeability, VE-cadherin transfers intracellular signals that contribute to vascular stabilization. However, the molecular mechanism by which VE-cadherin regulates vascular homoeostasis is still poorly understood. Here, we report that VE-cadherin expression and junctional clustering are required for optimal transforming growth factor-beta (TGF-beta) signalling in endothelial cells (ECs). TGF-beta antiproliferative and antimigratory responses are increased in the presence of VE-cadherin. ECs lacking VE-cadherin are less responsive to TGF-beta/ALK1- and TGF-beta/ALK5-induced Smad phosphorylation and target gene transcription. VE-cadherin coimmunoprecipitates with all the components of the TGF-beta receptor complex, TbetaRII, ALK1, ALK5 and endoglin. Clustered VE-cadherin recruits TbetaRII and may promote TGF-beta signalling by enhancing TbetaRII/TbetaRI assembly into an active receptor complex. Taken together, our data indicate that VE-cadherin is a positive and EC-specific regulator of TGF-beta signalling. This suggests that reduction or inactivation of VE-cadherin may contribute to progression of diseases where TGF-beta signalling is impaired."xsd:string |
| http://purl.uniprot.org/citations/18337748 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2008.46"xsd:string |
| http://purl.uniprot.org/citations/18337748 | http://purl.uniprot.org/core/author | "Liebner S."xsd:string |
| http://purl.uniprot.org/citations/18337748 | http://purl.uniprot.org/core/author | "Letarte M."xsd:string |
| http://purl.uniprot.org/citations/18337748 | http://purl.uniprot.org/core/author | "ten Dijke P."xsd:string |
| http://purl.uniprot.org/citations/18337748 | http://purl.uniprot.org/core/author | "Garre M."xsd:string |
| http://purl.uniprot.org/citations/18337748 | http://purl.uniprot.org/core/author | "Felici A."xsd:string |
| http://purl.uniprot.org/citations/18337748 | http://purl.uniprot.org/core/author | "Corada M."xsd:string |
| http://purl.uniprot.org/citations/18337748 | http://purl.uniprot.org/core/author | "Dejana E."xsd:string |
| http://purl.uniprot.org/citations/18337748 | http://purl.uniprot.org/core/author | "Rudini N."xsd:string |
| http://purl.uniprot.org/citations/18337748 | http://purl.uniprot.org/core/author | "Giampietro C."xsd:string |
| http://purl.uniprot.org/citations/18337748 | http://purl.uniprot.org/core/author | "Lampugnani M."xsd:string |
| http://purl.uniprot.org/citations/18337748 | http://purl.uniprot.org/core/author | "Swirsding K."xsd:string |
| http://purl.uniprot.org/citations/18337748 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18337748 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/18337748 | http://purl.uniprot.org/core/pages | "993-1004"xsd:string |
| http://purl.uniprot.org/citations/18337748 | http://purl.uniprot.org/core/title | "VE-cadherin is a critical endothelial regulator of TGF-beta signalling."xsd:string |
| http://purl.uniprot.org/citations/18337748 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/18337748 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18337748 |
| http://purl.uniprot.org/citations/18337748 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18337748 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQW9-mappedCitation-18337748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18337748 |
| http://purl.uniprot.org/uniprot/#_E9Q418-mappedCitation-18337748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18337748 |
| http://purl.uniprot.org/uniprot/#_Q62312-mappedCitation-18337748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18337748 |
| http://purl.uniprot.org/uniprot/#_Q63961-mappedCitation-18337748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18337748 |